An Insight into Pullulan and Its Potential Applications

Reddy, C. Nagendranatha; Mishra, Bishwambhar; Mandal, Sanjeeb Kumar; Agrawal, Dinesh Chand; Kruthiventi, Chandana

doi:10.1007/978-3-030-42215-8_15

Polysaccharides of Microbial Origin 2022

DOI: 10.1007/978-3-030-42215-8_15

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An Insight into Pullulan and Its Potential Applications

C. Nagendranatha Reddy

Bishwambhar Mishra

Sanjeeb Kumar Mandal

et al.

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2024

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Cited by 4 publications

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Progress in bioproduction, characterization and applications of pullulan: a review

Aquinas,

Chithra,

Bhat

2024

Polym. Bull.

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Pullulan is a biopolymer produced by various strains of the fungi Aureobasidium pullulans. It is made up of maltotriose units consisting of α-(1,6) and α-(1,4) glycosidic bonds. Pullulan was discovered by Bauer in 1938, characterized by Bernier in 1958 and named as ‘pullulan’ by Bender in 1959. Submerged fermentation is widely employed for pullulan production followed by downstream processing for recovery of pullulan. Factors such as nutrients, minerals, pH, temperature, surfactants, light intensity, and melanin intermediate affect its production. Various optimization methods such as Plackett Burman design, response surface methodology, and artificial neural networks have been utilised for enhancing the yield of pullulan. Pullulan yield as high as 62.52 g/L can be achieved using a 5 L fermenter under optimised conditions. It can be characterized by techniques such as nuclear magnetic resonance, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy. The biopolymer has remarkable properties which makes it an ideal candidate to be used in various applications such as the biomedical and pharmaceutical sectors, cosmetics, food, and wastewater treatment. Pullulan’s applications can be expanded by chemically modifying to obtain grafted pullulan, polymer blends, nanocomposites and hydrogels which have been gaining importance in recent years. Over the years, many patents using pullulan have been granted for different applications worldwide. This review sheds light on all these aspects of pullulan including its future scope. Graphical abstract

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Progress in bioproduction, characterization and applications of pullulan: a review

Aquinas,

Chithra,

Bhat

2024

Polym. Bull.

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A review of the fungal polysaccharides as natural biopolymers: Current applications and future perspective

Ali,

Alsharbaty,

Al-Tohamy

et al. 2024

International Journal of Biological Macromolecules

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Machine Learning-Based Optimization for Enhanced Pullulan Recovery from Aureobasidium pullulans

Sahu,

Mahanty,

Haldar

2024

Ind. Eng. Chem. Res.

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The solvent extraction protocol significantly influences the yield and purity of the exopolysaccharide recovery from cell-free broth. In this study, methanol, ethanol, isopropanol, acetone, and PEG-6000 were compared for the amount of pullulan recovery (PR), sucrose equivalent (SE), and protein impurity (PI) of the precipitate. The PR (7.0 g L −1 ) and SE (0.45 g g −1 ) from acetone had been significantly better than others. Quadratic and GA-optimized artificial neural network (ANN) models, developed from a central composite design, accurately predicted PR (R 2 : 0.996−0.998), SE (R 2 : 0.961−0.985), and PI (R 2 : 0.952−0.984) based on the pH, incubation time, and solvent-to-broth volume (S/B) ratio. Individually optimized PR (10.53 g L −1 ), SE (0.64 g g −1 ), and PI (1.05 mg g −1 ) from quadratic models are comparable to those obtained from ANN models. Multiobjective optimization with equal weighting suggests a moderate PR (quadratic model: 8.14 g L −1 , ANN: 6.77 g L −1 ) while maintaining SE and PI close to their optimal values. However, the relative importance of these objectives should be ascertained based on the intended application.

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An Insight into Pullulan and Its Potential Applications

Cited by 4 publications

References 42 publications

Progress in bioproduction, characterization and applications of pullulan: a review

Progress in bioproduction, characterization and applications of pullulan: a review

A review of the fungal polysaccharides as natural biopolymers: Current applications and future perspective

Machine Learning-Based Optimization for Enhanced Pullulan Recovery from Aureobasidium pullulans

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