An insight into synthetic Schiff bases revealing antiproliferative activities in vitro

2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead

“…Considering the pivotal role resorcinol moiety plays in Hsp90 suppression [15,16] and the importance of schiff bases (imines or azomethines) in cancer chemotherapy [17,18], we began our Hsp90 research program with structure based drug design of novel resorcinol containing imines using Malachite green assay which measures the ATPase activity of human Hsp90 [19]. This effort led to the discovery of a series of novel small molecule azomethines as Hsp90 inhibitors.…”

Antimicrobial Activity of 2-Nitro-6-[(4-Phenyl-Benzo[4,5]imidazo[1,2-a] Pyrimidin-2-ylimino)-Methyl]-Phenol: A Novel Schiff Base Compound

“…Benzimidazole and its derivatives have the capacity to interfere several microbial metabolic processes that in turn affect their growth and sometimes leading to cell death. They have shown good activity against bacteria [14], fungi [15], virus [16], parasites [4]. They also have good anti-inflammatory property [17] and are also good antioxidant agents [18].…”

Convenient synthesis and characterization of some novel benzothiazolone-based Schiff bases as potential pharmaceutically active agents

“…[10][11][12][13][14] Also, they are reported to possess diverse pharmacological activities. [15][16][17][18][19][20][21] In addition, benzothiazolone containing heterocycles systems have been incorporated into a wide variety of therapeutically interesting drug candidates 22 . Previous works were published, expanding the structure activity relationship of 6-benzoyl-2(3H)-benzothiazolone (S-14080) as an analgesic compound.…”