An insight into the biological activity and structure-based drug design attributes of sulfonylpiperazine derivatives

Kilbile, Jaydeo T.; Tamboli, Yasinalli; Gadekar, Suchita S.; Islam, Imadul; Supuran, Claudiu T.; Sapkal, Suryakant B.

doi:10.1016/j.molstruc.2023.134971

Cited by 6 publications

(1 citation statement)

References 175 publications

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“…Nitrogen-based heterocyclic compounds have drawn interest of researchers over the years, due to their biological importance [1][2][3][4][5]. The dihydropyrimidine nucleus, a doubly unsaturated six-membered ring possessing two nitrogen atoms at positions 1 and 3, is one of the most important nitrogencontaining heterocycles which was first synthesized by Pietro Biginelli in 1891 in the multicomponent Biginelli reaction [6].…”

Section: Introductionmentioning

confidence: 99%

Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Elshamsy,

Ali,

Osman

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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Dihydropyrimidines (DHPMs) are a class of nitrogen-containing heterocycles that have attracted considerable interest due to their great significance in organic and medicinal chemistry. In recent years, many biologically active molecules featuring DHPM moiety have been synthesized and biologically evaluated, some of which have served as potential leads for critical unmet pathological conditions such as the antimitotic Monastrol and the antiviral GLS4, which entered clinical trials a few years ago. This review discusses briefly the recent advances in DHPM-based bioactive compounds, their biological activities, and their mechanisms of action, which could provide references for future developments of more potent and selective leads.

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Section: Introductionmentioning

confidence: 99%

Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Elshamsy,

Ali,

Osman

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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Lasamide Containing Sulfonylpiperazines as Effective Agents for the Management of Glaucoma Associated Symptoms

Kilbile,

Sapkal,

Renzi

et al. 2024

ChemMedChem

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A series of 2,4‐dichloro‐5‐{[4‐(phenylsulfonyl)piperazin‐1‐yl]carbonyl}benzenesulfonamide were designed and synthesized through amidation of Lasamide 1 with substituted piperazines. The newly obtained compounds demonstrated remarkable inhibition potency and selectivity for the human (h) expressed Carbonic Anhydrase (CA; EC 4.2.1.1) II isoform. Selected compounds 7 and 9 were considered in an in vivo model of glaucoma and showed relevant performances with the latter being able to last the effect up to 4 hours. The results herein reported are in sustainment of Lasamide derivatives as a new class of compounds potentially exploitable for the management of uncontrolled IOP.

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Study of different interactions in piperazine benzoate and its effect on biological properties: Experimental and theoretical approach

R.,

Rathika,

Joselin Beaula

et al. 2024

Journal of Molecular Structure

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An insight into the biological activity and structure-based drug design attributes of sulfonylpiperazine derivatives

Cited by 6 publications

References 175 publications

Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Lasamide Containing Sulfonylpiperazines as Effective Agents for the Management of Glaucoma Associated Symptoms

Study of different interactions in piperazine benzoate and its effect on biological properties: Experimental and theoretical approach

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