An insight into the extraction and fractionation technologies of the essential oils and bioactive compounds in Rosmarinus officinalis L.: Past, present and future

Ali, Ameena; Chua, Bee Lin; Chow, Yin Hui

doi:10.1016/j.trac.2019.05.040

Cited by 71 publications

(68 citation statements)

References 82 publications

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“…Rosemary and sage are aromatic, medicinal plants that have received particular attention in the Lamiaceae family due to their aromatic and chemical composition [ 2 , 27 , 28 ], while bay laurel is a valuable medicinal plant from the Lauraceae family, which has been widely used as a spice and flavoring agent [ 19 ]. Due to the numerous bioactive compounds, the essential oils of these plants show a wide range of biological activities such as antimicrobial, preservative, antioxidant, and antifungal, which makes them valuable in a range of applications, from medicinal to the food industry [ 29 , 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the numerous bioactive compounds, the essential oils of these plants show a wide range of biological activities such as antimicrobial, preservative, antioxidant, and antifungal, which makes them valuable in a range of applications, from medicinal to the food industry [ 29 , 30 , 31 , 32 , 33 ]. Considering these valuable properties, the improvement of current and the development of novel essential oil extraction procedures is a subject of many recent studies [ 28 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Enzymatic, Ultrasound, and Reflux Extraction Pretreatments on the Yield and Chemical Composition of Essential Oils

et al. 2020

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The effect of different hydrodistillation pretreatments, namely, reflux extraction, reflux extraction with the addition of cell wall-degrading enzymes, and ultrasound, on the yield and chemical composition of essential oils of sage, bay laurel, and rosemary was examined. All pretreatments improved essential oil yield compared to no-pretreatment control (40–64% yield increase), while the oil quality remained mostly unchanged (as shown by statistical analysis of GC-MS results). However, enzyme-assisted reflux extraction pretreatment did not significantly outperform reflux extraction (no-enzyme control), suggesting that the observed yield increase was mostly a consequence of reflux extraction and enzymatic activity had only a minute effect. Thus, we show that ultrasound and reflux extraction pretreatments are beneficial in the production of essential oils of selected Mediterranean plants, but the application of enzymes has to be carefully re-evaluated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Enzymatic, Ultrasound, and Reflux Extraction Pretreatments on the Yield and Chemical Composition of Essential Oils

et al. 2020

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“…Calibration model was developed by principal component regression (PCR). From the data matrix 2/4 of it was used for the calibration and 1/4 was used for the validation while the remaining 1 4 was used for the prediction. Validation was done by K-fold cross-validation.…”

Section: Determination Of Color Of Rosemary Extractsmentioning

confidence: 99%

“…Rosemary (Rosmarinus officinalis L.) is an autochthonous Mediterranean herb from Lamiaceae family. From ancient times, rosemary has been used as flavoring agent and for medicinal purposes due to its intense aromatic odor and health benefits [1]. The biological activity of rosemary is mostly related to the phenolic compounds, such as carnosol, carnosic acid, and rosmarinic acid [2], and volatile compounds from essential oil like α-pinene, camphor, eucalyptol, or 1,8-cineole [3].…”

Section: Introductionmentioning

confidence: 99%

The Potential of High Voltage Discharges for Green Solvent Extraction of Bioactive Compounds and Aromas from Rosemary (Rosmarinus officinalis L.)—Computational Simulation and Experimental Methods

et al. 2020

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Rosemary (Rosmarinus officinalis L.) is a Mediterranean medicinal and aromatic plant widely used due to valuable bioactive compounds (BACs) and aromas. The aim of the study was to evaluate the extraction of intracellular compounds from rosemary combining experimental procedure by means of high voltage electrical discharge (HVED), with a theoretical approach using two computational simulation methods: conductor-like screening model for real solvents and Hansen solubility parameters. The optimal HVED parameters were as follows: frequency 100 Hz, pulse width 400 ns, gap between electrodes 15 mm, liquid to solid ratio 50 mL/g, voltage 15 and 20 kV for argon, and 20 and 25 kV for nitrogen gas. Green solvents were used, water and ethanol (25% and 50%). The comparison was done with modified conventional extraction (CE) extracted by magnetic stirring and physicochemical analyses of obtained extracts were done. Results showed that HVED extracts in average 2.13-times higher total phenol content compared to CE. Furthermore, nitrogen, longer treatment time and higher voltage enhanced higher yields in HVED extraction. HVED was confirmed to have a high potential for extraction of BACs from rosemary. The computational stimulation methods were confirmed by experimental study, ethanol had higher potential of solubility of BACs and aromas from rosemary compared to water.

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“…However, there are several disadvantages associated with these methods, such as high energy consumption and carbon dioxide emission [ 44 ]. In order to overcome these challenges and to enhance extraction yield and EOs quality, a novel promising “green” techniques that are non-thermal, cost-efficient, sustainable, and capable of producing EOs with similar or improved characteristics have been developed [ 42 , 43 , 44 ]. These techniques include supercritical fluid extraction, microwave-assisted extraction, ultrasound-assisted extraction, pressurized liquid extraction, accelerated solvent extraction, microwave steam distillation, and steam diffusion, pulse electric field extraction, enzyme-assisted extraction, molecular distillation, and instantaneous controlled pressure drop processes [ 42 , 43 , 45 ].…”

Section: Essential Oils As Antimicrobial Agentsmentioning

confidence: 99%

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-based strategies for developing nanoscaled carriers for their efficient delivery might offer potential solutions. Owing to their biocompatibility, biodegradability, low toxicity, ability to target a tissue specifically, and primary structures that allow for the attachment of various therapeutics, magnetite nanoparticles (MNPs) are an example of such nanocarriers that could be used for the efficient delivery of EOs for antimicrobial therapies. The aim of this paper is to provide an overview of the use of EOs as antibacterial agents when coupled with magnetite nanoparticles (NPs), emphasizing the synthesis, properties and functionalization of such NPs to enhance their efficiency. In this manner, systems comprising EOs and MNPs could offer potential solutions that could overcome the challenges associated with biofilm formation on prosthetic devices and antibiotic-resistant bacteria by ensuring a controlled and sustained release of the antibacterial agents.

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An insight into the extraction and fractionation technologies of the essential oils and bioactive compounds in Rosmarinus officinalis L.: Past, present and future

Cited by 71 publications

References 82 publications

Effect of Enzymatic, Ultrasound, and Reflux Extraction Pretreatments on the Yield and Chemical Composition of Essential Oils

Effect of Enzymatic, Ultrasound, and Reflux Extraction Pretreatments on the Yield and Chemical Composition of Essential Oils

The Potential of High Voltage Discharges for Green Solvent Extraction of Bioactive Compounds and Aromas from Rosemary (Rosmarinus officinalis L.)—Computational Simulation and Experimental Methods

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

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