An insight into the health benefits of fermented soy products

Jayachandran, Muthukumaran; Xu, Baojun

doi:10.1016/j.foodchem.2018.07.158

Cited by 180 publications

(119 citation statements)

References 74 publications

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“…The regulation of Nrf2 signalling pathway in fish intestine after adding ETSP might be related to the improvement of IGF‐1. Jayachandran and Xu () found that ETSP improved the serum IGF‐1 in mice. Gui, Liu, Shao, and Xu () found that another plant protein hydrolysate (cottonseed meal protein hydrolysate) replacing the cottonseed meal also improved the serum IGF‐1 in crucian carp ( Carassius auratus gibelio ).…”

Section: Discussionmentioning

confidence: 99%

“…These results suggested that ETSP could improve The regulation of Nrf2 signalling pathway in fish intestine after adding ETSP might be related to the improvement of IGF-1. Jayachandran and Xu (2019) found that ETSP improved the serum IGF-1 in mice. Gui, Liu, Shao, and Xu (2010) found that another plant protein hydrolysate (cottonseed meal protein hydrolysate)…”

Section: Etsp Regulated Intestinal Gene Expressions Of Antioxidant mentioning

confidence: 95%

“…In vitro biochemical studies have shown that ETSP can strongly remove radicals and inhibit lipid peroxidation (Moure, Domınguez, & Parajo, ; Sarmadi & Ismail, ). Recent research also indicated that ETSP improved the insulin‐like growth factor 1 (IGF‐1) of plasma in mice (Jayachandran & Xu, ), while the IGF‐1 could promote antioxidant gene expressions through Nrf2 signalling pathway in human neuroblastoma SH‐SY5Y cells (Wang et al, ). These appear that ETSP may be related to the Nrf2 signalling pathway in fish intestine to influence activities of antioxidant enzymes and relative gene expressions, which is valuable for investigation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary enzyme‐treated soy protein on the immunity and antioxidant status in the intestine of juvenile Jian carp ( Cyprinus carpio var. Jian)

et al. 2019

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This study was conducted to evaluate the hypothesis that enzyme‐treated soy protein (ETSP) can save the fish dietary protein, and further investigated the mechanism for saving effect by studying the effects of ETSP on intestinal immune response and antioxidant status in juvenile Jian carp (Cyprinus carpio var. Jian). Compared with the high‐protein diet, results showed that decreasing 2% of dietary protein increased the protein carbonyl (PC) content, decreased the anti‐hydroxyl radical capacity (AHR) and superoxide dismutase (SOD) activity and increased the relative expressions of pro‐inflammatory cytokine (p < 0.05). The low‐protein diet might impair the intestinal health, so as to reduce fish growth performance. After adding 1.5% or 2% of ETSP to the low‐protein diet, results indicated that (1) ETSP decreased the relative expressions of pro‐inflammatory cytokine and increased the relative expressions of anti‐inflammatory cytokine (p < 0.05). (2) ETSP decreased malondialdehyde (MDA) and PC content (p < 0.05), improved activities of antioxidant enzymes, glutathione (GSH) content, relative expressions of antioxidant enzymes and Nrf2, which were even much higher than the high‐protein diet (p < 0.05). All the above data suggested that optimal level of ETSP can save 2% of fish dietary protein which might be partly attributed to improve intestinal health through regulating intestinal immunity response and antioxidant status.

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Section: Discussionmentioning

confidence: 99%

Section: Etsp Regulated Intestinal Gene Expressions Of Antioxidant mentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Effect of dietary enzyme‐treated soy protein on the immunity and antioxidant status in the intestine of juvenile Jian carp ( Cyprinus carpio var. Jian)

et al. 2019

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“…55 Strong anticancer properties have been discovered in soybeans. 56 L-asparaginase production by Bradyrhizobium sp. (Lupinus) has been shown, 57 but there is no report showing that B. japonicum.…”

Section: Sequence Retrievalmentioning

confidence: 99%

In silico identification and characterization of antineoplastic asparaginase enzyme from endophytic bacteria

et al. 2020

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It is generally accepted that L‐asparagine is an important amino acid required for the fast growth of cells. Cancerous cells receive this amino acid from extracellular sources. The depletion of L‐asparagine from its surrounding environments by asparaginase enzyme can be used as a therapeutic strategy in cancer patients. This therapeutic enzyme is produced commercially mainly from bacteria such as Escherichia coli and Erwinia chrysanthemi. The side effects of such drugs have persuaded scientists to find new enzyme sources. In this study, in silico approach was applied to investigate L‐asparaginase producing endophytic bacteria that produce more compatible enzymes within the body. Protein–protein basic local alignment search tool with E. coli and E. chrysanthemi asparaginase enzyme sequences against 262 endophytic bacteria were performed. The results with identity more than 35%, coverage more than 80%, and E‐value less than 10−4 were selected. Then, some of bioinformatics tools were used to characterize them. A total of nine sequences consisting of seven known and two hypothetical proteins were identified in six bacterial species. The results showed that some of the asparaginase enzymes produced by endophytic bacteria possess more suitable immunological indices compared with asparaginase enzymes of E. coli and E. chrysanthemi. Herbaspirillum rubrisubalbicans was predicted to produce a nonallergen and nonantigen asparaginase enzyme. The number of antigenic determinants was predicted to be lower in asparaginase enzymes produced by Bacillus amyloliquefaciens, H. rubrisubalbicans, and H. seropedicae. Moreover, the number of high‐scored B‐cell epitopes was lower in enzyme sequences related to the mentioned bacteria and Paenibacillus polymyxa. The number of discontinuous epitopes and the number of T‐cell epitopes were lower in B. amyloliquefaciens produced enzymes. Therefore, the therapeutic use of these enzymes is possible.

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“…Recent epidemiological studies have explored the associations between consumption of soy and isoflavone and a wide series of outcomes (including mortality, cancers, cardiovascular disease, gynecological, metabolic, musculoskeletal, endocrine, neurological, and renal outcomes) . Most of these studies were not interventional in design, dependent on evidence from cohort, case‐control or cross‐sectional studies and frequently generalized by outcome through meta‐analysis and systematic review.…”

Section: Introductionmentioning

confidence: 99%

Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta‐Analyses of Observational Studies and Randomized Trials in Humans

Zhuang

et al. 2019

Molecular Nutrition Food Res

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Scope To assess the existing evidence of associations between consumption of soy and isoflavone and multiple health outcomes. Methods and results This is an umbrella review of meta‐analyses and systematic reviews of randomized trials and observational studies in humans. 114 Meta‐analyses and systematic reviews are identified with 43 unique outcomes. Soy and isoflavone consumption seems more beneficial than harmful for a series of health outcomes. Beneficial associations are identified for cancers, cardiovascular disease, gynecological, metabolic, musculoskeletal, endocrine, neurological, and renal outcomes, particularly in perimenopausal women. Harmful association is only found for gastric cancer (RR: 1.17, 95% CI: 1.02–1.36) for high intake of miso soup (1–5 cups per day) in male. Conclusion Generally, soy and isoflavone consumption is more beneficial than harmful. The results herein support promoting soy intake as part of a healthy diet. Randomized controlled trials are necessary to confirm this finding.

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An insight into the health benefits of fermented soy products

Cited by 180 publications

References 74 publications

Effect of dietary enzyme‐treated soy protein on the immunity and antioxidant status in the intestine of juvenile Jian carp ( Cyprinus carpio var. Jian)

Effect of dietary enzyme‐treated soy protein on the immunity and antioxidant status in the intestine of juvenile Jian carp ( Cyprinus carpio var. Jian)

In silico identification and characterization of antineoplastic asparaginase enzyme from endophytic bacteria

Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta‐Analyses of Observational Studies and Randomized Trials in Humans

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