An insight into the health-promoting effects of taxifolin (dihydroquercetin)

Sunil, Christudas; Xu, Baojun

doi:10.1016/j.phytochem.2019.112066

Cited by 204 publications

(135 citation statements)

References 61 publications

Supporting

Mentioning

135

Contrasting

Order By: Relevance

“…In this article, 12 components in CNE were detected by UHPLC-Q-TOF-MS/MS. Among the 12 components, garcinol, pyridoxine, (-)-epicatechin, phloretin, quercetins, rutin, nicotinic acid, taxifolin and rhein showed promising pharmacological activities in the management of inflammation, oxidative stress, and liver disorders (Arauz et al 2015;Behera et al 2016;Ren et al 2016;Bu et al 2018;Roh et al 2018;Huang et al 2019;Lee et al 2019;Sunil and Xu 2019).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Zhang

Feng

et al. 2020

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Camellia nitidissima Chi (Theaceae) is an evergreen shrub, the leaves of which are used in many medicinal applications. Objective: To characterize the chemical composition of a 10% aqueous ethanol extract of C. nitidissima leaves (CNE), and to explore the protective effect of the extract against acute liver injury (ALI) in rats. Materials and methods: Male Sprague-Dawley rats were divided into six groups (n ¼ 10): control and negative (0.5% CMC-Na, 5 mL/kg/d), thiopronin (20 mg/kg/d) and CNE (40, 80 and 160 mg/kg/d). All groups were treated for seven consecutive days, and then, except for the control, carbon tetrachloride was administered intraperitoneally. The biochemical parameters, mRNAs, and proteins were analyzed using enzyme-linked immunoassays kits, quantitative polymerase chain reaction and western blot. Chemical components were identified using mass spectroscopy, and the phenol and flavonoid content determined by ultraviolet spectrophotometry. Results: Pre-treatment with CNE (160 mg/kg) attenuated the pathological changes in liver tissues and decreased alanine transaminase (62 and 60%), aspartate transaminase (49 and 53%) and malondialdehyde (35 and 42%) levels in serum and liver tissues. Moreover, CNE reduced the concentrations of reactive oxygen species (55%), tumour necrosis factor-a (26%), interleukin-1b (19%) and IL-6 (19%) and blocked the nuclear translocation of p65. Pre-treatment with CNE increased anti-heme oxygenase-1 (40%), superoxide dismutase (108%) and glutathione (97%) levels through upregulating nuclear factor erythroid-2-related factor 2. Twelve compounds were detected; the content of phenols and flavonoids was determined as 34.474 ± 1.026 and 15.228 ± 0.422 mg/g crude drug in CNE, respectively. Discussion and conclusions: These results suggested that CNE is a promising agent for functional food and hepatoprotective drug against ALI.

show abstract

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Zhang

Feng

et al. 2020

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…Taxifolin [ 93 ] dose-dependently inhibited the proliferation, migration, and invasion of MDA-MB-231 triple-negative breast cancer cells, promoted MET, and inhibited lung metastases in the 4T1 xenograft mouse model [ 94 ].…”

Section: Targeting Metastatic Cancermentioning

confidence: 99%

Flavonoids in Cancer Metastasis

Líšková

Koklesová

Samec

et al. 2020

Cancers

137

128

View full text Add to dashboard Cite

Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various health beneficiary effects. The effects of flavonoids against cancer are associated not only with early stages of the cancer process, but also with cancer progression and spread into distant sites. Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-β and other contributors of the complex process of metastatic spread. Moreover, flavonoids modulated also the expression of genes associated with the progression of cancer and improved inflammatory status, a part of the complex process involved in the development of metastasis. Flavonoids also documented clear potential to improve the anti-cancer effectiveness of conventional chemotherapeutic agents. Most importantly, flavonoids represent environmentally-friendly and cost-effective substances; moreover, a wide spectrum of different flavonoids demonstrated safety and minimal side effects during long-termed administration. In addition, the bioavailability of flavonoids can be improved by their conjugation with metal ions or structural modifications by radiation. In conclusion, anti-cancer effects of flavonoids, targeting all phases of carcinogenesis including metastatic progression, should be implemented into clinical cancer research in order to strengthen their potential use in the future targeted prevention and therapy of cancer in high-risk individuals or patients with aggressive cancer disease with metastatic potential.

show abstract

“…AL (78.054 ± 0.307 mg/g of extract) and AF (36.012 ± 0.392 mg/g of extract) contain gallic acid ( Table 1 ), which induces apoptosis in cancer cells [ 15 ]. Additionally, the highest amount of taxifolin, which exhibits promising pharmacological activities, including the management of tumors and liver disorders [ 16 ], was detected in AL (16.977 ± 0.167 mg/g of extract). Although AB exhibited a low level of cytotoxic activity compared with other extracts, various polyphenolic compounds, including kaempferol, rhamnetin, tangeretin, vanillic acid, and ferulic acid, have been identified.…”

Section: Resultsmentioning

confidence: 99%

Polyphenolic Composition and Anti-Melanoma Activity of White Forsythia (Abeliophyllum distichum Nakai) Organ Extracts

Yoo

Kim

Hyun

2020

Plants

View full text Add to dashboard Cite

Abeliophyllum distichum Nakai, commonly called white forsythia, is a monotypic genus endemic to Korea. Although A. distichum is mainly used as an ornamental plant because of its horticultural value, recent studies have demonstrated its bioactivities, including antioxidant and anti-inflammatory activities, prompting us to investigate the potential anticancer effect of A. distichum organ extracts (leaves, fruit, and branches) against human melanoma SK-MEL-2 cells. The methanol extract of A. distichum leaves (AL) exhibited dose- and time-dependent cytotoxicities against SK-MEL-2 cells but not against HDFa human dermal fibroblasts. Based on high-performance liquid chromatography analysis, we identified 18 polyphenolic compounds from A. distichum organ extracts and suggest that differences in anticancer activity between organ extracts should be caused by different compositions of polyphenolic compounds. Additionally, the Annexin V/propidium iodide staining assay and analysis of caspase activity and expression indicated that AL induced cell death, including early and late apoptosis, as well as necrosis, by inducing the extrinsic pathway. Furthermore, we analyzed the differentially expressed genes between mock- and AL-treated cells using RNA-seq technology, suggesting that the anti-melanoma action of AL is mediated by down-regulation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Taken together, these results shed light on the potential use of A. distichum as a green resource with potent anti-melanoma activity.

show abstract

An insight into the health-promoting effects of taxifolin (dihydroquercetin)

Cited by 204 publications

References 61 publications

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Flavonoids in Cancer Metastasis

Polyphenolic Composition and Anti-Melanoma Activity of White Forsythia (Abeliophyllum distichum Nakai) Organ Extracts

Contact Info

Product

Resources

About

An insight into the health-promoting effects of taxifolin (dihydroquercetin)

Cited by 204 publications

References 61 publications

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Flavonoids in Cancer Metastasis

Polyphenolic Composition and Anti-Melanoma Activity of White Forsythia (Abeliophyllum distichum Nakai) Organ Extracts

Contact Info

Product

Resources

About

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling