An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Al-Maiahy, Thabat J; Alexiou, Athanasios; Mukerjee, Nobendu; Batiha, Gaber El‐Saber

doi:10.1080/02648725.2022.2122291

Cited by 10 publications

(6 citation statements)

References 68 publications

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“… 126 It has been shown that viral infections including SARS‐CoV‐2 infection can suppress the endogenous antioxidant system including glutathione transferase, superoxide dismutase, and catalase in human alveolar cells causing epithelial injury. 127 , 128 …”

Section: Oxidative Storm In Covid‐19mentioning

confidence: 99%

“…126 It has been shown that viral infections including SARS-CoV-2 infection can suppress the endogenous antioxidant system including glutathione transferase, superoxide dismutase, and catalase in human alveolar cells causing epithelial injury. 127,128 Higher oxidative stress in Covid-19 also reduces serum albumin which acts as an antioxidant and antiinflammatory. In a retrospective study, low albumin serum level was correlated with Covid-19 severity.…”

Section: Oxidative Storm In Covid-19mentioning

confidence: 99%

“…As well, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is also stimulated during SARS‐CoV‐2 infection‐causing generation ROS/RNS with the propagation of oxidative burst 126 . It has been shown that viral infections including SARS‐CoV‐2 infection can suppress the endogenous antioxidant system including glutathione transferase, superoxide dismutase, and catalase in human alveolar cells causing epithelial injury 127,128 …”

Section: Oxidative Storm In Covid‐19mentioning

confidence: 99%

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Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era

Alomair

Al-Kuraishy

Al-Gareeb

et al. 2023

Immunity Inflam & Disease

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Coronavirus disease 2019 (Covid-19) is caused by a novel severe acute respiratory syndrome coronavirus virus type 2 (SARS-CoV-2) leading to the global pandemic worldwide. Systemic complications in Covid-19 are mainly related to the direct SARS-CoV-2 cytopathic effects, associated hyperinflammation, hypercytokinemia, and the development of cytokine storm (CS). As well, Covid-19 complications are developed due to the propagation of oxidative and thrombotic events which may progress to a severe state called oxidative storm and thrombotic storm (TS), respectively. In addition, inflammatory and lipid storms are also developed in Covid-19 due to the activation of inflammatory cells and the release of bioactive lipids correspondingly. Therefore, the present narrative review aimed to elucidate the interrelated relationship between different storm types in Covid-19 and the development of the mixed storm (MS). In conclusion, SARS-CoV-2 infection induces various storm types including CS, inflammatory storm, lipid storm, TS and oxidative storm. These storms are not developing alone since there is a close relationship between them. Therefore, the MS seems to be more appropriate to be related to severe Covid-19 than CS,

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Section: Oxidative Storm In Covid‐19mentioning

confidence: 99%

Section: Oxidative Storm In Covid-19mentioning

confidence: 99%

Section: Oxidative Storm In Covid‐19mentioning

confidence: 99%

See 1 more Smart Citation

Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era

Alomair

Al-Kuraishy

Al-Gareeb

et al. 2023

Immunity Inflam & Disease

Self Cite

View full text Add to dashboard Cite

show abstract

“…74 Moreover, SARS-CoV-2 protein E induces activation of Ca 2+ channels in ER and Golgi membranes that change cytosolic Ca 2+ concentrations with activation of the nod-like receptor pyrin 3 (NLRP3) inflammasome, causing over-production of IL-1β. [75][76][77] Exaggerated immune responses and activation of the NLRP3 inflammasome are linked with COVID-19 severity through the induction release of pro-inflammatory cytokines with the development of ALI/ARDS. 78,79 High pro-inflammatory cytokines from cytosolic Ca +2 -induced NLRP3 inflammasome activation also promote release of Ca +2 from ER by activating RyRs.…”

Section: Role Of Dantrolene In Sars-cov-2-induced Inflammationmentioning

confidence: 99%

Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden

Alkazmi

Al-Kuraishy

Al-Gareeb

et al. 2023

Clin Exp Pharma Physio

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Dantrolene (DTN) is a ryanodine receptor (RyR) antagonist that inhibits Ca 2+ release from stores in the sarcoplasmic reticulum. DTN is mainly used in the management of malignant hyperthermia. RyRs are highly expressed in immune cells and are involved in different viral infections, including severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), because Ca 2+ is necessary for viral replication, maturation and release. DTN can inhibit the proliferation of SARS-CoV-2, indicating its potential role in reducing entry and pathogenesis of SARS-CoV-2. DTN may increase clearance of SARS-CoV-2 and promote coronavirus disease 2019 (COVID-19) recovery by shortening the period of infection. DTN inhibits N-methyl-D-aspartate (NMDA) mediated platelets aggregations and thrombosis. Therefore, DTN may inhibit thrombosis and coagulopathy in COVID-19 through suppression of platelet NMDA receptors. Moreover, DTN has a neuroprotective effect against SARS-CoV-2 infection-induced brain injury through modulation of NMDA receptors, which are involved in excitotoxicity, neuronal injury and the development of neuropsychiatric disorders. In conclusion, DTN by inhibiting RyRs may attenuate inflammatory disorders in SARS-CoV-2 infection and associated cardio-pulmonary complications. Therefore, DNT could be a promising drug therapy against COVID-19. Preclinical and clinical studies are warranted in this regards.

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“…The catalytic sites of the aforementioned enzymes are not blocked when they interact with the corresponding coronavirus S protein; however, any coronavirus receptor is downregulated because the virus is internalized with it through endocytosis [ 105 ]. In fact, DPP-IV and ANPEP are found in membrane domains associated with caveolae [ 106 ].…”

Section: Pathogenesis Of the Virusesmentioning

confidence: 99%

Human Coronavirus Cell Receptors Provide Challenging Therapeutic Targets

et al. 2023

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Coronaviruses interact with protein or carbohydrate receptors through their spike proteins to infect cells. Even if the known protein receptors for these viruses have no evolutionary relationships, they do share ontological commonalities that the virus might leverage to exacerbate the pathophysiology. ANPEP/CD13, DPP IV/CD26, and ACE2 are the three protein receptors that are known to be exploited by several human coronaviruses. These receptors are moonlighting enzymes involved in several physiological processes such as digestion, metabolism, and blood pressure regulation; moreover, the three proteins are expressed in kidney, intestine, endothelium, and other tissues/cell types. Here, we spot the commonalities between the three enzymes, the physiological functions of the enzymes are outlined, and how blocking either enzyme results in systemic deregulations and multi-organ failures via viral infection or therapeutic interventions is addressed. It can be difficult to pinpoint any coronavirus as the target when creating a medication to fight them, due to the multiple processes that receptors are linked to and their extensive expression.

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An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection

Cited by 10 publications

References 68 publications

Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era

Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era

Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden

Human Coronavirus Cell Receptors Provide Challenging Therapeutic Targets

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