An Insight of Clinical Evidence of Ayurveda Interventions in the Management
of COVID-19 Patients

Maideen, Naina Mohamed Pakkir; Balasubramaniam, Rajkapoor; Manavalan, Gobinath; Balasubramanian, Kumar; Nivedhitha, S; Thirumal, M; S, Vasanth Kumar

doi:10.2174/1871526522666220321152504

IDDT

2022

DOI: 10.2174/1871526522666220321152504

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An Insight of Clinical Evidence of Ayurveda Interventions in the Management of COVID-19 Patients

Naina Mohamed Pakkir Maideen

Rajkapoor Balasubramaniam²,

Gobinath Manavalan³

et al.

Abstract: Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused Coronavirus disease 2019 (COVID-19) and the patients with COVID-19 might be managed with traditional medicine like Ayurveda alone or in combination with standard allopathic treatment as Ayurveda is one of the oldest traditional medicinal systems followed by millions around the globe. Methods: The literature was searched in databases such as LitCOVID, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, EMBASE, and refer… Show more

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Cited by 3 publications

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An umbrella review on treatments and therapeutic options for COVID-19

SeyedAlinaghi,

Afsahi,

Molla

et al. 2023

Russian Journal of Infection and Immunity

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Introduction: As the COVID-19 pandemic continues to pose a significant challenge toglobal health, effectivetherapeutic optionsfor preventing and treating the disease have become increasingly important. We aimed to provide an update on current treatments and therapeutic options for COVID-19 patients. Methods: The purpose of this umbrella review is to explore the current treatments and therapeutic options for COVID-19 patients. Keywords and their combinations were searched across online databases in Embase, PubMed/MEDLINE, Web of Science, and Scopus spanning from July 1, 2020, through March 3, 2023. Publications were selected for data extraction in two steps based on the study inclusion/ exclusion criteria. The study adheres to the PRISMA checklist as well as NIH bias risk and quality assessment tool. Results: In this review, 28 relevant articles were selected for the final qualitative synthesis. The majority of included studies had reported on the efficacy of Lopinavir/Ritonavir (n=4), Ivermectin (n=3), Baricitinib (n=2), Tocilizumab (n=2), Remdesivir (n=2), ACEI / ARB (n=2), Vitamin D (n=2), Molnupiravir (n=2), Traditional Chinese medicine (TCM) (n=2), Convalescent plasma transfusion (CPT) n=2) and hydroxychloroquine (n=2) in treating COVID-19. It appeared that Baricitinib, Remdesivir, ACEI/ARB, TCM, and CPT may have beneficial effects on reducing mortality, hospitalization duration, and disease severity in COVID-19 patients. Other interventions, such as Lopinavir/Ritonavir, Ivermectin, and Vitamin D, and Hydroxychloroquine did not show clear benefits or had inconclusive results. Conclusion: This umbrella review provides a comprehensive overview of the current evidence on the effectiveness and safety of various pharmacological and non-pharmacological interventions for COVID-19. These results provide an updated overview of the current landscape for COVID-19 treatments, highlighting potential avenues for further research and clinical practice. It is crucial to continue monitoring emerging evidence and conducting rigorous studies to guide the development and optimization of therapeutic strategies against COVID-19.

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An umbrella review on treatments and therapeutic options for COVID-19

SeyedAlinaghi,

Afsahi,

Molla

et al. 2023

Russian Journal of Infection and Immunity

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A review of Ayurvedic measures for preventing COVID-19 and promoting health during pregnancy

Singh,

Sengar,

Jha

2024

J Indian Syst Med

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With the fourth year of the pandemic under its belt, the SARS-CoV-2 virus (COVID-19) disease is no longer deemed a public health emergency, but rather a persistent health issue. COVID-19 is one among the many diseases caused by severe acute respiratory syndrome coronavirus-2. Two waves of COVID-19 infections have recently emerged in India, with 2.8 million confirmed cases and 1,95,123 fatalities as of April 26, 2021. Typically, individuals have symptoms such as fever, dry cough, and malaise, which usually subside within a few days. However, in rare instances, these symptoms can escalate to respiratory distress, organ failure, and ultimately death. According to the World Health Organization, pregnant women are at a higher risk of contracting COVID-19 and may experience more severe symptoms than the general population. This is owing to their adaptive physiological changes and weakened immunological condition. Additionally, there is an elevated risk of premature delivery. Susceptible populations require special attention, efforts, and care to protect them from the coronavirus. No specific drug has been discovered for pregnant women (COVID-19) to date. Thus, preventive actions are the primary focus worldwide. Considering the current COVID-19 crisis, strengthening one’s immune system is very crucial, and in recent weeks, there has been much interest in Ayush practices that boost immunity. This article describes numerous Rasayana medicines, both single and compound, as well as preventive measures. This study primarily aims to understand the Ayurvedic perspective of COVID-19 during pregnancy and to offer Ayurvedic measures for immune regulation, health promotion, and prevention. By adopting Ayurvedic measures, the immunity of pregnant women can be enhanced, and COVID-19 will be prevented well, which will lessen the burden of the disease worldwide.

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Safety and Efficacy of Chyawanprash as a Prophylaxis Treatment for COVID-19: A Systematic Review and Meta-Analysis of Randomized Control Trials

Sharma,

Sethuraman,

Kumari

2024

Cureus

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Amidst the multifaceted challenges posed by COVID-19, interest in complementary and alternative medicine (CAM) has risen. Chyawanprash (CP), an Ayurvedic formulation, is recognized for its multifunctional properties. This systematic review aims to evaluate its safety and effectiveness as a COVID-19 prophylactic. A literature search was conducted for articles published within the past three years from databases such as Cochrane Library, PubMed, and Google Scholar. A total of 1008 articles were identified, and 34 were included for full-text screening, resulting in five randomized controlled trials (RCTs) meeting the eligibility criteria. Meta-analysis was performed using a random effects model, with results represented in odds ratio (95% confidence intervals (CIs)), and publication bias presented through funnel plots. The five clinical trials conducted in India analyzed 153,343 participants. In the meta-analysis, the odds ratios for COVID-19-positive patients, COVID-19-positive in symptomatic patients, healthcare resource utilization (HCRU), and adverse events were 0.45 (95% CI 0.06-3.08, p = 0.41), 0.37 (95% CI 0.01-12.86, p = 0.58), 0.95 (95% CI 0.18-5.04, p = 0.95), and 0.94 (95% CI 0.63-1.40, p = 0.75) respectively. Notably, significant heterogeneity was observed among studies including both COVID-19-positive cases (I 2 = 80%, p = 0.007) and symptomatic COVID-19 cases (I 2 = 83%, p = 0.01), whereas non-significant zero heterogeneity was observed in HCRU (I 2 = 0%, p = 0.74) and adverse events (I 2 = 0%, p = 1.00). The meta-analysis reveals a trend in the efficacy of CP as prophylaxis for COVID-19 treatments. However, owing to high heterogeneity and bias, further research is recommended.

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An Insight of Clinical Evidence of Ayurveda Interventions in the Management of COVID-19 Patients

Cited by 3 publications

References 58 publications

An umbrella review on treatments and therapeutic options for COVID-19

An umbrella review on treatments and therapeutic options for COVID-19

A review of Ayurvedic measures for preventing COVID-19 and promoting health during pregnancy

Safety and Efficacy of Chyawanprash as a Prophylaxis Treatment for COVID-19: A Systematic Review and Meta-Analysis of Randomized Control Trials

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