An Insight to Oral Epithelial Dysplasia

Abstract

Oral dysplasia is a potentially precancerous lesion diagnosed histologically. While the risk of progression is associated with histological grade, it is currently impossible to predict accurately which lesions will progress. Although most oral pathologists recognize and accept the criteria for grading epithelial dysplasia based on architectural and cytological changes, there can be considerable interexaminer and intraexaminer variation in the assessment of the presence or absence and the grade of oral epithelial dysplasia. This article reviews the alterations, criteria, different grading systems and the markers used for assessing the malignant transformation of epithelial dysplasia.

A Clinicopathologic and Epidemiologic Study of Chronic White Lesions in the Oral Mucosa

“…Histopathology remains the most useful and essential investigation to detect premalignant lesions, to assess the severity of epithelial dysplasia, and to predict possible malignant transformation. 10 There are no fixed guidelines a clinicoPatHoloGic and ePideMioloGic study of cHronic wHite lesions in tHe oral Mucosa as to how much tissue should be obtained for biopsy or from which area it should be obtained in a large lesion. The common view is that biopsy should be taken from the edge of the lesion along with some adjacent normal-appearing mucosa.…”

Immunohistochemical characterization of cyclin dependent kinase-4 in different histological grades of oral leukoplakia and oral squamous cell carcinoma

“…WHO system which was used in our study, (2005) is based on tissue architecture and cytology and it grades dysplasia in to hyperplasia (increased cell numbers without cellular atypia), mild dysplasia (minimal architectural changes typically confined to the basal third of epithelium), moderate dysplasia (marked architectural changes seen in basal two-thirds of epithelium), severe dysplasia (marked architectural changes involving more than two-thirds of epithelium) and carcinoma in situ (severe form of epithelial dysplasia characterized by full thickness or almost full thickness cytological and architectural changes). [ 28 29 ]…”

Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders

“…The word dysplasia denotes abnormal growth. [ 25 ] The dysplastic alterations may revert to normal when the underlying inciting stimulus is removed. Dysplastic features in stratified squamous epithelium are characterized by cellular atypia and loss of normal maturation and stratification.…”