An Insight To Pullulan: A Biopolymer in Pharmaceutical Approaches

Kumar, Deepak; Saini, Nisha; Pandit, Vinay; Ali, Sajid

doi:10.14419/ijbas.v1i3.101

Cited by 28 publications

(17 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ The FTIR spectrum of crude EPS (Fig. 2) displayed a broad intense peak at around 3219.19 cm -1 which showed similar type of spectra found in various studies [17], [18]. This band represented the stretching vibration of the hydroxyl groups in the carbohydrate ring.…”

Section: Resultssupporting

confidence: 69%

Characterization and Safety Evaluation of Exopolysaccharide Produced by Rhodotorula minuta BIOTECH 2178

Ramirez¹

2016

IJFE

View full text Add to dashboard Cite

Yeast exopolysaccharide (EPS) are composed of unique sugar units, which offers an interesting perspective with respect to various food applications. This study aimed to characterize the EPS from Rhodotorula minuta BIOTECH 2178. Toxicological assessment of the EPS was investigated to ensure that it is safe for human consumption. The yeast EPS revealed high total sugar composition (59.21-62-47%) and low protein content (17.19%). FTIR spectrum showed prominent functional group such as hydroxyl, carboxyl, beta-linkages, glucose, mannan, and aromatic ring. SEM micrograph of EPS revealed a highly compact with elongated granular structures. Toxicological examination of EPS (50-400mg EPS/kg bodyweight) did not show any symptoms of toxicity and mortality after 14 days administration of aqueous crude EPS. Hematological and histopathological examination in the liver showed no significant alteration between the experimental and control groups. Hence, the highly compact and unique functional properties of Rhodotorula minuta EPS showed its potential application in the industry as thickening and stabilizing agent.  Index Terms-yeast exopolysaccharide, Rhodotorula minuta, spectroscopy, mice, histopathological analysis

show abstract

Section: Resultssupporting

confidence: 69%

Characterization and Safety Evaluation of Exopolysaccharide Produced by Rhodotorula minuta BIOTECH 2178

Ramirez¹

2016

IJFE

View full text Add to dashboard Cite

show abstract

“…The polymers most employed in the development of buccal mucoadhesives, as observed in a patent survey, are amide gums, carboxymethyl cellulose, carrageenan, locust bean gum, pullulan, xanthan and konjac, as well as plasticizers such as glycerol, maltitol, olive and canola oils (among other oils), propylene glycol, sorbitol and xylitol. Among these raw materials, pullulan has been extensively used as a drug delivery carrier due to its biocompatibility and biodegradability (Kumar et al, 2012;Xiao et al, 2012). Pullulan and its derivatives have numerous demonstrated uses in foods, pharmaceuticals, cosmetics, biomedical and pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

“…Following fermentation, the cells are harvested and duly disrupted using either enzymes or physical forces. Pullulan is then extracted using a simple water extraction process (Mishra et al, 2011;Kumar et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Development of a buccal mucoadhesive film for fast dissolution: mathematical rationale, production and physicochemical characterization

et al. 2013

View full text Add to dashboard Cite

The validity of a mathematical rationale for preparation of a fast-dissolving buccal mucoadhesive was tested. A buccal mucoadhesive biopolymeric formulation has been developed having pullulan as the main component. The formulation was duly evaluated physicochemically, via assays for intrinsic viscosity (resulting in 71.61 cm 3 g À1 ), differential scanning calorimetry analysis (resulting in a Tg ¼ 63 C), thermogravimetric analysis (244-341 C), moisture content determinations (14%, w/w), dissolution timeframe (41.6 s), mucoadhesion force (40 kg/cm 2 ), scanning electron microscopy analyses (critical ray under 1.0 mm), mechanic strength (tensile strength ¼ 58 N/mm 2 , deformation ¼ 4.4%). The mucoadhesive formulation exhibited important characteristics for a drug carrier, that is, a 6 cm 2 area, a fast dissolution timeframe, an adequate mucoadhesivity, resistance to both oxygen and water vapor penetration, increased viscosity in solution (ranging from 33.2 cm 3 /g to 71.61 cm 3 /g), easy molding, suitable water solubility and transparency.

show abstract

“…Chemically, pullulan is a polysaccharide consisting of maltotriose units and produced from starch by the fungus Aureobasidium pullulans [78]. Pullulan is white to off-white tasteless, odorless, non-toxic, non-carcinogenic powder which forms clear transparent film with considerable mechanical strength and it is biodegradable and impermeable to oxygen [79,80].…”

Section: Pullulanmentioning

confidence: 99%

Hot melt extrusion: An industrially feasible approach for casting orodispersible film

Jani

Patel

2015

Asian Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Film forming polymers Plasticizers Die swell phenomenon Quality by design Scale up a b s t r a c t Over the recent few decades, many groups of formulation scientists are concentrating on rapid release dosage forms in oral cavity. Among all fast release dosage forms, orodispersible films are successful to attract pharmaceutical industry due to ease of formulation and extension patent life. Films are popular in patients too because of quick onset and user friendliness of dosage form. From the beginning, solvent casting has been selected as method of choice for manufacturing of orodispersible films. Solvent casting has been proved as a benchmark technology because of ease in product development, process optimization, process validation and technology transfer to production scale despite of some drawbacks like more number of unit operations involved and consumption of large quantity of solvents with controlled limits of organic volatile impurities in final formulation. The application ofhot-melt extrusion (HME) in the pharmaceutical industry is consecutively increasing due to its proven innumerable advantages like solvent free continuous process with fewer unit operations and better content uniformity. Very few development activities has been initiated in the field of hot melt extruded orodispersible films so far. This extensive review covers detailed discussion of heavy duty industrial extruders, selection of downstream equipments, selection of excipients, common problems found in formulations and their remedies. Successive part of review addresses identification of critical quality attributes, quality target profile of product, criticality in selection of process parameters and material for substantial simulation in laboratory scale and production for successful technology transfer.

show abstract

An Insight To Pullulan: A Biopolymer in Pharmaceutical Approaches

Cited by 28 publications

References 44 publications

Characterization and Safety Evaluation of Exopolysaccharide Produced by Rhodotorula minuta BIOTECH 2178

Characterization and Safety Evaluation of Exopolysaccharide Produced by Rhodotorula minuta BIOTECH 2178

Development of a buccal mucoadhesive film for fast dissolution: mathematical rationale, production and physicochemical characterization

Hot melt extrusion: An industrially feasible approach for casting orodispersible film

Contact Info

Product

Resources

About