An Instant Underwater Tissue Adhesive Composed of Catechin‐Chondroitin Sulfate and Cholesterol‐Polyethyleneimine

Abstract

Due to the safety issue and poor underwater adhesion of current commercially available bioadhesives, they are hard to apply to in vivo physiological environments and more diverse medical use conditions. In this study, a novel and facile bioadhesive for underwater medical applications are designed based on the coacervation of electrostatic interactions and hydrophobic interactions, with the introduction of catechin as a provider of catechol moieties for adhesion to surrounding tissues. The orange‐colored bio‐adhesive, named PcC, is generated within seconds by mixing catechin‐modified chondroitin sulfate and cholesterol chloroformate‐modified polyethyleneimine with agitation. In vitro mechanical measurements prove that this novel PcC bio‐adhesive is superior in underwater adhesion performance when applied to cartilage. Animal experiments in a rat mastectomy model and rat cartilage graft implantation model demonstrate its potential for diverse medical purposes, such as closing surgical incisions, reducing the formation of seroma, and tissue adhesive applied in orthopedic or cartilage surgery.

Catechin‐Functionalized Cationic Lipopolymer Based Multicomponent Nanomicelles for Lung‐Targeting Delivery

“…Synthesis of Poly(ethylenimine)-Cholesterol (PEI-Chol, P): Briefly, 3 g of pre-dried PEI (M w 25 000) was dissolved in 10 mL of anhydrous methylene chloride with 0.1 mL of triethylamine, the mixture was stirred on ice. [52][53][54] 1 g of cholesteryl chloroformate was dissolved in 5 mL of anhydrous cold methylene chloride and slowly added to the PEI solution over a period of ≈30 min. The mixture was stirred for 2 h on ice, then the reaction was carried out at room temperature for 2-3 h. The resulting product was filtered through filter paper and dropped into a large amount of stirring ether, then the white precipitate was washed 3 times with ether.…”

The application strategy of liposomes in organ targeting therapy

“…To overcome paclitaxel resistance in lung cancer, Wang J et al prepared P‐glycoprotein antibody‐conjugated PEG‐coated immunoliposomes (Pab‐PTX‐L) to enhance cellular uptake of paclitaxel in tumor cells, and ultimately achieving the inhibitory effects on tumor growth (Figure 4e) (J. Wang, Suo, & Zhang, 2023). In addition to paclitaxel, liposomes also play an important role in improving the bioavailability and reducing systemic toxicity of other highly effective anti‐cancer drugs, such as silymarin (SL) (Gheybi et al, 2023), curcumin (Negro et al, 2023; Y. Wang, Huang, et al, 2023), deferoxamine (DFO) (Guo et al, 2023), and catechins (Jin et al, 2023).…”

Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

“…[103] They can encapsulate hydrophobic BCs in the core, and the shell hydrophilic corona allows loading hydrophilic BCs. For example, these common cargos include catechin, [104] curcumin, [105] tanshinone IIA, [106] paclitaxel [107] and cathelicidin. [107] The structure of nanomicelles is shown in Figure 4A.…”