An instructive case of amlodipine‐induced reversible granulomatous CD30⁺T‐cell pseudolymphoma

Abstract

We report an unusual case of drug-associated granulomatous CD30 + T-cell pseudolymphoma secondary to amlodipine. A 55-year-old Chinese man presented with a 6-month eruption of disseminated erythematous dermal papulonodules and annular infiltrated plaques over his neck and limbs symmetrically. Histopathology revealed a perivascular and interstitial infiltrate of histiocytes, eosinophils and morphologically normal lymphocytes associated with CD30 expression. The eruption improved rapidly after discontinuation of amlodipine and did not recur.

Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature

“…The lowest prevalence of CD30‐positive reports between drug classes was observed among monoclonal antibodies (37.5%) ( p ‐value <0.001). Of 25 cases with T‐cell receptor rearrangement, 21 (84.0%) of them were polyclonal and four (16.0%) were monoclonal 30–33 . Two cases of monoclonal CPL have been reported after using amlodipine, and cases of phenytoin and metoprolol/hydrochlorothiazide‐induced CPL have been found.…”

“…Of 25 cases with T-cell receptor rearrangement, 21 (84.0%) of them were polyclonal and four (16.0%) were monoclonal. [30][31][32][33] Two cases of monoclonal CPL have been reported after using amlodipine, and cases of phenytoin and metoprolol/ hydrochlorothiazide-induced CPL have been found.…”

CD30 in Cutaneous Pathology

“…Inflammatory drug eruptions have been sometimes reported to contain a large amount of CD30-positive cells. 88–93 Mainly antiepileptic drugs have been reported to have such findings. 79 Some of these infiltrates have shown an intralymphatic distribution, mimicking an intravascular lymphoma.…”