An integral topical gel for cellulite reduction: results from a double-blind, randomized, placebo-controlled evaluation of efficacy

Abstract

BackgroundCellulite is a serious cosmetic concern for most of the 90% of women affected by it.ObjectiveTo assess the clinical efficacy of a complex integral anti-cellulite gel.MethodsThis double-blind, randomized, placebo-controlled study involved 44 healthy women, aged 25–55 years. Subjects had a normal to slightly overweight body mass index and presented slight to moderate cellulite on their thighs, buttocks, and/or hips at baseline. Subjects were randomly assigned to either the treated or placebo group and accordingly applied the active product or placebo on their hips, stomach, buttocks, and thighs, twice daily for 3 months. Skin tonicity, orange-peel aspect, and stubborn cellulite were assessed at day 0, 28, 56, and 84. A self-evaluation questionnaire was completed by all volunteers.ResultsAt the end of the study, an average of 81% of the subjects applying the active product presented improvement in their cellulite condition versus 32% for the placebo group (all descriptors and sites combined). At day 84, skin tonicity, orange-peel appearance, and stubborn cellulite were improved in a significant manner (P<0.05) over placebo, on all studied areas. Skin tonicity improved on average by +41% for buttocks, +35% for hips, and +31% for thighs. Orange peel appearance was reduced on average by −25% for buttocks, −22% for hips, and −22% for thighs. Stubborn cellulite was reduced on average by −19% for buttocks, −24% for hips, and −22% for thighs. Circumference measurements decreased in a significant manner (P<0.05) over placebo, for the abdomen (average value of −1.1 cm) and thighs (average value of −0.8 cm). The product was well tolerated and perceived by the volunteers themselves as better performing than placebo on all criteria.ConclusionAll results validate the efficacy of the present integral formulation to significantly reduce signs of cellulite and reshape the silhouette.

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“…Dėl to pagerėja celiulito būklė, oda tampa lygesnė, stangresnė ir gerėja jos spalva. Manualinių procedūrų poveikiui sustiprinti naudojamas anticeliulitinis masažinis aliejus ir kremas, su veikliųjų medžiagų kompleksu (Dupont, 2014).…”

Effects of repeated use of a commercial topical lotion on subcutaneous fat thickness in resistance‐trained male athletes

“…14 Similarly, the twice-daily application of a mixed ingredient topical fat-loss gel for 3 months on the thighs of female participants 13 improved the cellulite appearance in 81% of the participants compared with 32% in the placebo group. However, it is worthwhile to note that the aforementioned studies 6,[13][14][15] were sponsored by the manufacturers of the products being examined, and one study was conflicted by the concomitant prescription of a hypocaloric diet and exercise intervention. 14 One very popular fat loss lotion for athletes is advertised to athletes as a "body shaping serum" and "fat mobiliser" that can achieve regional stubborn body fat reduction by mobilizing fat from the subcutaneous fat layer.…”

“…Topical lotions have received some attention from the public given the non‐invasive nature of their administration, 6‐8 delivering the active ingredients directly to the site of action. Although there is a body of literature that questions the benefits of these products, 9‐11 some studies have provided evidence that some of the compounds included in some topical fat loss lotions, such as aminophylline and caffeine, can cause a reduction in subcutaneous fat (shown via ultrasound and caliper measurement) and improve the appearance of cellulite 6,12‐15 . For instance, twice‐daily application of a mixed ingredient topical lotion for 28 days on the thighs of female participants was reported to result in a greater reduction in thigh skinfold thickness (−3.7 mm vs. −2.0 mm) and thigh fat mass (−100 g vs. −53 g) compared with a placebo lotion 14 .…”

“…Although there is a body of literature that questions the benefits of these products, 9 , 10 , 11 some studies have provided evidence that some of the compounds included in some topical fat loss lotions, such as aminophylline and caffeine, can cause a reduction in subcutaneous fat (shown via ultrasound and caliper measurement) and improve the appearance of cellulite. 6 , 12 , 13 , 14 , 15 For instance, twice‐daily application of a mixed ingredient topical lotion for 28 days on the thighs of female participants was reported to result in a greater reduction in thigh skinfold thickness (−3.7 mm vs. −2.0 mm) and thigh fat mass (−100 g vs. −53 g) compared with a placebo lotion. 14 Similarly, the twice‐daily application of a mixed ingredient topical fat‐loss gel for 3 months on the thighs of female participants 13 improved the cellulite appearance in 81% of the participants compared with 32% in the placebo group.…”

“… 6 , 12 , 13 , 14 , 15 For instance, twice‐daily application of a mixed ingredient topical lotion for 28 days on the thighs of female participants was reported to result in a greater reduction in thigh skinfold thickness (−3.7 mm vs. −2.0 mm) and thigh fat mass (−100 g vs. −53 g) compared with a placebo lotion. 14 Similarly, the twice‐daily application of a mixed ingredient topical fat‐loss gel for 3 months on the thighs of female participants 13 improved the cellulite appearance in 81% of the participants compared with 32% in the placebo group. However, it is worthwhile to note that the aforementioned studies 6 , 13 , 14 , 15 were sponsored by the manufacturers of the products being examined, and one study was conflicted by the concomitant prescription of a hypocaloric diet and exercise intervention.…”