An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma

Yang, Yong; Li, Dianbo; Yang, Yang; Jiang, Gening

doi:10.3892/mmr.2015.3557

Cited by 17 publications

(16 citation statements)

References 44 publications

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“…However, other evidence highlights FNDC3B as oncogene. First, FNDC3B is usually amplified [7, 33] and highly expressed in HCC and other cancers [7, 31, 34–36]. Cai et al .…”

Section: Discussionmentioning

confidence: 99%

FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma

Lin¹,

Lin²,

Chen³

et al. 2016

Oncotarget

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Recurrence and metastasis are common in hepatocellular carcinoma (HCC) and correlate with poor prognosis. We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in HCC metastasis. Overexpression of FNDC3B in HCC cell lines enhanced cell migration and invasion. On the other hand, knockdown of FNDC3B using short-hairpin RNA reduced tumor nodule formation in both intra- and extra-hepatic metastasis. High levels of FNDC3B were observed in metastatic HCCs and correlated with poor patient survival and shorter recurrence time. Mutagenesis and LC-MS/MS analyses showed that FNDC3B promotes cell migration by cooperating with annexin A2 (ANXA2). Furthermore, FNDC3B and ANXA2 expression correlated negatively with patient survival. Our results indicate that FNDC3B behaves like an oncogene by promoting cell migration. This suggests FNDC3B could serve as a biomarker and therapeutic target for HCC metastasis.

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“…However, other evidence highlights FNDC3B as oncogene. First, FNDC3B is usually amplified [7, 33] and highly expressed in HCC and other cancers [7, 31, 34–36]. Cai et al .…”

Section: Discussionmentioning

confidence: 99%

FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma

Lin¹,

Lin²,

Chen³

et al. 2016

Oncotarget

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“…Effects of NS5ABP37 on cell proliferation, apoptosis , and cycle distribution . Previous studies reported that NS5ABP37 is associated with human cancers such as HCC, esophageal squamous cell cancer, glioblastoma, primary urethral clear‐cell adenocarcinoma, chronic lymphocytic leukemia, and prostate cancer . Therefore, we attempted to further study the effect of NS5ABP37 on the growth of cancer cells as well as normal hepatocytes.…”

Section: Resultsmentioning

confidence: 99%

NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis

et al. 2017

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The molecular mechanism underlying non‐alcoholic fatty liver disease progression to hepatocellular carcinoma (HCC) remains unknown. In this study, immunohistochemistry staining results showed that NS5ABP37 protein, which is in a state of lower expression in tumor tissues, decreased with increasing degree of HCC malignancy. Two cell models, HepG2 and L02, were used to analyze the mechanism between NS5ABP37 and HCC. In agreement, NS5ABP37 protein overexpression significantly suppressed cell proliferation, caused G1/S cell cycle arrest, and induced apoptosis by increasing caspase‐3/7 activity and cleaved caspase‐3 levels. In addition, NS5ABP37 overexpression resulted in decreased intracellular triglyceride and total cholesterol contents, with level reduction in sterol regulatory element‐binding proteins (SREBPs) and downstream effectors. Furthermore, NS5ABP37 overexpression decreased SREBP1c and SREBP2 levels by reducing their respective promoters. Finally, reactive oxygen species levels and endoplasmic reticulum stress were both induced by NS5ABP37 overexpression. These findings together indicate that NS5ABP37 inhibits cancer cell proliferation and promotes apoptosis, by altering SREBP‐dependent lipogenesis and cholesterogenesis in HepG2 and L02 cells and inducing oxidative stress and endoplasmic reticulum stress.

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“…FNDC3B is one of the most common genes up-regulated in cancer tissues, regardless of the cancer type and tumor origin [18]. Recent studies have found that FNDC3B is highly expressed in breast cancer, esophageal cancer, glioblastoma, and hepatocellular carcinoma, and is associated with cancer cell proliferation, invasion and metastasis [19][20][21][22][23]. Therefore, we hypothesized that FNDC3B promotes cell migration and tumorigenesis in PC.…”

Section: Introductionmentioning

confidence: 98%

Clinical Significance and Prognostic Value of the Expression of Fibronectin Type III Domain Containing 3B in Pancreatic Carcinoma

Ma¹,

Liao²,

Du³

et al. 2020

Preprint

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Background: Pancreatic carcinoma (PC) is one of the most aggressive cancers affecting human health. Identifying candidate biomarkers is essential for the early diagnosis and good prognosis of PC. Fibronectin type III domain containing 3B (FNDC3B) promotes many types of cancer, but its role in pancreatic cancer is not clear. The purpose of this study was to investigate the relationship between the expression of FNDC3B and incidence of PC. Methods: We downloaded data related to the levels of FNDC3B mRNA in patients of PC from the Cancer Genome Atlas (TCGA) database, and conducted in-depth research on this data and its clinical significance through the R tools. We used GO and KEGG enrichment analyses to study the genes and signaling pathways that may be regulated by FNDC3B. Results: The results showed that the level of FNDC3B mRNA in PC tissues was higher than that in the normal tissues, and this was associated with proliferation and lymph node metastases of PC. Increased levels of FNDC3B mRNA also predict poor prognosis for the patients with PC. In addition, enhanced levels of FNDC3B mRNA were involved in the regulation of cell junction, tissue and epithelial cell migration, and several signal transduction pathways, including notch, TGF-β, VEGF, and Wnt. Conclusions: In short, high levels of FNDC3B mRNA may be associated with progression of PC and indicate a poor prognosis in patients with PC.

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An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma

Cited by 17 publications

References 44 publications

FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma

FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma

NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis

Clinical Significance and Prognostic Value of the Expression of Fibronectin Type III Domain Containing 3B in Pancreatic Carcinoma

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