One nation with the highest risk of climate catastrophes is Pakistan. Pakistan’s geographical nature makes it susceptible to natural hazards. Pakistan is facing regional differences in terms of climate change. The frequency and intensity of natural hazards due to climate change vary from place to place. There is an urgent need to recognize the spatial variations in natural hazards inside the country. To address such problems, it might be useful to map out the areas that need resources to increase resilience and accomplish adaptability. Therefore, the main goal of this research was to create a district-level map that illustrates the multi-hazard zones of various regions in Pakistan. In order to comprehend the geographical differences in climate change and natural hazards across Pakistan, this study examines the relevant literature and data currently available regarding the occurrence of natural hazards in the past. Firstly, a district-level comprehensive database of Pakistan’s five natural hazards (floods, droughts, earthquakes, heatwaves, and landslides) was created. Through consultation with specialists in related areas, hazard and weighting factors for a specific hazard were specified based on the structured district-level historical disaster database of Pakistan. After that, individual and multi-hazard ratings were computed for each district. Then, using estimated multi-hazard scores, the districts of Pakistan were classified into four zones. Finally, a map of Pakistan’s multi-hazard zones was created per district. The study results are essential and significant for policymakers to consider when making decisions on disaster management techniques, that is, when organizing disaster preparedness, mitigation, and prevention plans.