An Integrated Microfabricated Device for Dual Microdialysis and On-Line ESI-Ion Trap Mass Spectrometry for Analysis of Complex Biological Samples

Fan, Xianping; Lin, Yuehe; Wen, Jian; Matson, Dean W.; Smith, Richard D.

doi:10.1021/ac981400w

Cited by 131 publications

(111 citation statements)

References 35 publications

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“…403 High-throughput analyses, with lower contamination and disposability, are other features of microfabricated devices that allow the fast screening of proteomic samples in the clinical field. Applications also include the analysis of low-molecular-weight compounds such as peptides 404 or pharmaceutical 405 samples. Henion and co-workers investigated the use of microfabricated devices coupled with MS for the determination of several drugs.…”

Section: Applicationsmentioning

confidence: 99%

18 Coupling CE and microchip-based devices with mass spectrometry

Schappler¹,

Veuthey²,

Rudaz³

2008

Capillary Electrophoresis Methods for Pharmaceutical Analysis

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Section: Applicationsmentioning

confidence: 99%

18 Coupling CE and microchip-based devices with mass spectrometry

Schappler¹,

Veuthey²,

Rudaz³

2008

Capillary Electrophoresis Methods for Pharmaceutical Analysis

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“…The potential of mass spectrometry for biological warfare agent detection and identification has been advanced by the development of electrospray ionization and the introduction of new ion manipulation and measurement capabilities afforded by FTICR and quadrupole ion trap mass spectrometry. Combined with rapid sample processing in microfabricated devices (Liu et al 1998;Xiang et al 1999), the potential now exists for more broadly applicable and highly specific, selective, and sensitive field instrumentation.…”

Section: Technical Accomplishmentsmentioning

confidence: 99%

FY 1999 Laboratory Directed Research and Development annual report

Hughes¹

2000

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The images on the cover are computer simulations of the complex [Na]+ [edta]4-molecule (a tank complexing agent) using two three-dimensional codes, NWGrid and OSO. On the left is a volume mesh generated by NWGrid. The mesh fills the space between the molecular charge surface, which encloses the atoms, and a n exploded copy of that surface, slightly offset from the inner surface. There are 33 atoms in the molecule: 10 carbons (dark gray), two nitrogens (blue), one sodium (transparent cyan), eight oxygens (red), and 12 hydrogens (light gray). The volume is filled by a multiple scale-length mesh that is finest near the inner molecular charge surface, where field electric interactions a r e most complex, a n d coarsest a t the outer edge of the near-field extent.The O S 0 image on the right shows the same complex defined by each atom's characteristic van der Waals radius. The central sodium atom h a s been made transparent to reveal the atoms and structure behind it. The geometry-defining O S 0 file was used as input into NWGrid, which then generated the NWGrid surfaces and volume mesh.This work was performed by Janet Jones-Oliveira and Joseph Oliveira in their LDRD project, "Conservative Laws in Support of Reactive Transport." The project develops new algorithms for modeling hydrodynamics, subsurface transport, and molecular chemistry interactions. This work produces grids on which to compute complex geometries for modeling multiple computational and physical scales.NWGrid, the flagship code of the Applied Mathematics Group's "Center for Grid Generation and Unstructured Methods Development," is a three-dimensional, full-physics, first principles, timedomain, free-Lagrange code that was developed for parallel processing using unstructured grids. It is a library of user-callable tools that provide mesh generation, mesh optimization, and dynamic mesh maintenance in three dimensions. Regions within arbitrarily complicated geometries are defined as combinations of bounding surfaces where the surfaces are described analytically or as collections of points in space. O S 0 (developed by Los Alamos National Laboratory) is a geometry editor and volume renderer that defines geometries from which meshes are generated. The geometries may be defined interactively in terms of intersections and unions of surfaces or via input of Computer Aided Design output. DISCLAIMERPortions of this document may be illegible in electronic image products. Images are produced from the best available original document. PNNL-13203 UC-400 LDRD funding also allowed researchers at Pacific Northwest to make significant contributions in an effort to better understand global climate change and the transport and fate of subsurface contaminants. Today, we are using LDRD to explore the next frontier of environmental science and technology-improving knowledge on how environmental contaminants affect health.From LDRD-funded work on cell signaling, we now have programmatic funding to increase our understanding of the health effects of radiation exposure at ve...

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“…The use of microchannels has been used to increase mass transport rates in hemodialysis [9][10][11][12]. As a result, microchannel hemodialyzers can be made smaller capable of using less hemodialysis membrane, the key cost driver in producing hemodialyzers.…”

Section: Introductionmentioning

confidence: 99%

The Hermeticity of Compression Seals in Microchannel Hemodialyzers

Paul

Ward

2014

Journal of Micro and Nano-Manufacturing

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Most end stage renal disease patients receive kidney hemodialysis three to four times per week at central medical facilities. At-home kidney dialysis increases the convenience and frequency of hemodialysis treatments which has been shown to produce better patient outcomes. One limiting factor in realizing home hemodialysis treatments is the cost of the hemodialyzer. Microchannel hemodialyzers produced using compression sealing techniques show promise for reducing the size and cost of hemodialyzers. Challenges include the use of a 25 μm thick elastoviscoplastic (EVP) mass transfer membrane for gasketing. This paper provides a framework for understanding the hermeticity of these compression seals. The mechanical properties of a Gambro AN69ST membrane are determined and used to establish limits on the dimensional tolerances of the polycarbonate (PC) laminae containing sealing bosses used to seal the hemodialyzer. The resulting methods are applied to the fabrication of a hemodialysis device showing constraints on the scaling of this method to larger device sizes. The resulting hemodialysis device is used to perform urea mass transfer experiments without leakage.

show abstract

An Integrated Microfabricated Device for Dual Microdialysis and On-Line ESI-Ion Trap Mass Spectrometry for Analysis of Complex Biological Samples

Cited by 131 publications

References 35 publications

18 Coupling CE and microchip-based devices with mass spectrometry

18 Coupling CE and microchip-based devices with mass spectrometry

FY 1999 Laboratory Directed Research and Development annual report

The Hermeticity of Compression Seals in Microchannel Hemodialyzers

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