The extreme temperature has become more frequent and intense due to global warming, particularly in dry regions, causing devastating impacts on humans and ecosystems. The transboundary Amu river basin (ARB) is the most vulnerable region in Central Asia (CA) to extreme weather linked to climate change. This study aimed to project warm and cold extremes in ARB for three Shared Socioeconomic Pathways (SSP1-2.6, SSP2-4.5, SSP3-7.0 and SSP5-8.5) and two time-horizons, 2020–2059 and 2060-2099, using daily maximum (Tmax) and minimum temperature (Tmin) simulations of global climate models (GCMs) of Coupled Model Inter-comparison Project phase six (CMIP6). Results revealed that the basin's west experiences more hot extremes and the east more cold extremes. Climate change would cause a significant increase in the annual mean of Tmax and Tmin. However, the increase in mean Tmin would be much higher (5.0ºC ) than the mean Tmax (4.6ºC ). It would cause an increase in the hot extremes and a decrease in the cold extremes in the basin. The higher increase in the hot extremes would be in the west, while the higher decrease in the cold extreme in the basin's east. The number of days above 40℃ would increase from 45 to 60 days in the basin's west and northwest compared to the historical period. The number of days below -20℃ would decrease up to 45 days in the basin's east. Overall, the decrease in cold extremes would be much faster than the increase in hot extremes.