In this work, a fast and efficiently design method has been introduced. This design process consists of the overall design and the detailed design. For the overall design, one-dimensional pipe-network computations are employed to obtain several design cases quickly at the beginning. Meanwhile the solid domain geometry and mesh with cooling structures, i.e., film holes, impingement holes, and ribs have been generated to carry out three-dimensional (3-D) heat conduction calculations. Based on the above, a detailed design has been performed by 3-D conjugate heat transfer calculations. The results show that both the average temperature and the mass flow maximum errors between the pipe-network and 3-D conjugate heat transfer calculations are about 10%. In this article, the cooling structure of a gas turbine blade is designed with this platform. The final design results show that the maximum dimensionless temperature on the blade surface is 0.813, i.e., lower than the design requirement. The dimensionless mass flow rate in the first cooling inlet is 0.0168, and the mass flow rate in the secondary inlet is 0.0231.