An integrated screening method for paralytic shellfish toxins and their analogues based on fragmentation characteristics using an orbitrap-based ultrahigh-performance liquid chromatography-high-resolution mass spectrometry

Liang, Longhui; Li, Chunzheng; Fang, Junjian; Li, Hui; Wu, Shengming; Zhao, Junqing; Li, Jiaxin; He, Kun; Dong, Fangting

doi:10.1016/j.foodchem.2023.137502

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2024

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Cited by 3 publications

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Recent advances and challenges in the analysis of natural toxins

Lemmink,

Straub,

Bovee

et al. 2024

Advances in Food and Nutrition Research

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Recent advances and challenges in the analysis of natural toxins

Lemmink,

Straub,

Bovee

et al. 2024

Advances in Food and Nutrition Research

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Determination of hydrophilic marine biotoxins in bivalve molluscs by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)

Besbes,

Monser,

Nabli

et al. 2024

Journal of Food Composition and Analysis

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Paralytic Shellfish Poisoning (PSP) Toxins in Bivalve Molluscs from Southern Italy Analysed by Liquid Chromatography Coupled with High-Resolution Mass Spectrometry (UHPLC-HRMS/MS)

Gallo,

Lambiase,

Duro

et al. 2024

Toxins

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A new method for simultaneous determination by liquid chromatography coupled with high resolution mass spectrometry (UHPLC-HRMS/MS) of 14 paralytic shellfish poisoning toxins (PSP), that is, Saxitoxin, Neosaxitoxin, Gonyautoxins and their respective variants, in bivalve molluscs, is herein described. The samples were extracted by acetic acid solution, then analysed by UHPLC coupled with a Q-Exactive Orbitrap Plus high resolution mass spectrometer, by electrospray ionization mode (ESI) with no further clean up step. The analysis was carried out by monitoring both the exact mass of the molecular precursor ion of each compound (in mass scan mode, resolution at 70,000 FWHM) and its respective fragmentation patterns (two product ions) with mass accuracy greater than 5 ppm. The analytical performance of the method was evaluated calculating trueness, as mean recoveries of each biotoxin, between 77.8% and 111.9%, a within-laboratory reproducibility (RSDR) between 3.6% and 12.2%, the specificity, the linearity of detector response, and the ruggedness for slight changes The results of the validation study demonstrate this method fits for the purposes of the official control of PSP toxins in molluscs. The results of two years of monitoring in local mussel farms are also reported, showing that no significant concerns for food safety in the monitored productions.

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An integrated screening method for paralytic shellfish toxins and their analogues based on fragmentation characteristics using an orbitrap-based ultrahigh-performance liquid chromatography-high-resolution mass spectrometry

Cited by 3 publications

References 31 publications

Recent advances and challenges in the analysis of natural toxins

Recent advances and challenges in the analysis of natural toxins

Determination of hydrophilic marine biotoxins in bivalve molluscs by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)

Paralytic Shellfish Poisoning (PSP) Toxins in Bivalve Molluscs from Southern Italy Analysed by Liquid Chromatography Coupled with High-Resolution Mass Spectrometry (UHPLC-HRMS/MS)

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