Yagya Therapy is an ancient Vedic therapy. Using specific herbs for management of the disease, this novel approach can provide a supportive care in various conditions. Besides, it involves a holistic approach with pulmonary inhalation of herbal vapors through Pranayama. In the thyroid condition, hyper and hypo thyroid, there is imbalance of the T3, T4 and TSH hormones along with complains in associated with quality of life. The present study evaluated thyroid hormonal levels and quality of life in 18 thyroid patient after giving 40 days of Yagya Therapy with application of herbal mixtures for hormonal balance as supportive care. Patients were without any change in the drug and dose in past 6 months. The pre and post evaluation after Yagya Therapy revealed that in just 40 days of Yagya Therapy as supportive care, it helped to achieve the desired pattern in the hyperthyroid patients. In hypothyroid patients (n=9), pattern of increase in the T4 and T3 levels and decrease in TSH level and in the hyperthyroid patients (n=3), decrease in the T4 and T3 level and increase in TSH level were observed (p=0.06). In addition patients reported significant improvement in quality of life in physical weakness (p-value 0.0078), breathing issues (p-value 0.0078), sleep issues (p-value 0.0176), stress (p-value 0.002), indicating the potential of Yagya Therapy in treating and managing Thyroid condition. Yagya Therapy has great potential for management of chronic condition of Thyroid through both balancing thyroid hormones as well as by improving quality of life.