An integrative approach to define chemical exposure threshold limits for endangered sea turtles

Dogruer, Gulsah; Kramer, Nynke I.; Schaap, Iris; Hollert, Henner; Gaus, Caroline; Merwe, Jason P. van de

doi:10.1016/j.jhazmat.2021.126512

Cited by 6 publications

(5 citation statements)

References 44 publications

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“…At the time of the 6th mass extinction, the anthropogenic pressures threatening all species of marine turtles are considerable and the threat of the contagious neoplastic bropapillomatosis seem to increase, affecting northern areas of the globe where the disease had not been observed before (Duffy et al (2018), Yetsko et al (2021)). 2 The results of this research in Tintamarre island in the Caribbean concur with previous publications describing that macro-algae and Cd are probable environmental factors triggering the clinical expression of the disease in juvenile marine turtles (Van Houtan et al (2010), Dogruer et al (2021)). The observation of early stages of bropapillomatosis in the resident population of juvenile and sub-adult Chelonia mydas is nonetheless contradicting the pristine conditions of Tintamarre bays (Jones et al (2015), Duffy et al (2018), Yetsko et al (2021)).…”

Section: Discussionsupporting

confidence: 87%

“…These results differ from previous publications where Chelonia mydas's bropapillomatosis was strongly linked to the water quality of the foraging bays of the green turtles (Jones et al (2015), Duffy et al (2018), Yetsko et al (2021)). The concentration of the trace metallic element Cd measured in 2018 in leaves of Thalassia testudinum seagrass meadows of Tintamarre nonetheless exceeded the recommended standard for Chelonia mydas of 0,1 µg/g of dry forage (Dogruer et al (2021)) and its concentration may signi cantly vary throughout the year. Non calcareous macroalguae have been largely covering Tintamarre's reefs and a rm that they may be a signi cant cotrigger of bropapillomatosis at the site (Van Houten et al, (2010), Jones et al (2015)).…”

Section: Discussionmentioning

confidence: 86%

“…Concentrations of elements with long biogeological halflives in Chelonia mydas tissues, such as Cd, are dose and age dependent, tending to dilute as the turtle grow, which can explain the sensitivity of juvenile green turtles to trace metallic pollutants' toxicity. For instance, neritic forage Cd concentrations of 0.10, 0.13, and 0.19 µg/g of dry forage would result in 10%, 20% and 50% kidney cell mortality (Dogruer et al (2021)). However Tintamarre bay in Saint Martin (FWI) showed very low pollution in trace metallic elements tested both in 2017 and 2018 in Thalassia testudinum rhizomes and leaves.…”

Section: Studies Of Baie Blanche Seagrass Meadowsmentioning

confidence: 99%

“…Tintamarre is listed as a bay showing pristine conditions regarding the Thalassia testudinum seagrass meadow characteristics (Kerninon F. (2020)). Nevertheless, when considering Cd concentrations in Thallassia testudinum (Kerninon F. (2020)), results showed a notable variation between the concentration in leaves and rhizomes of Thalassia testudinum (Table 1 and Table 2), a signi cant annual variation (Table 2), and in 2018, exceeded the threshold of 0,1 µg/g of dry forage, susceptible to induce, after a prolonged exposure above this level, adverse health effects on organs of Chelonia mydas (Dogruer et al (2021)).…”

Section: Studies Of Baie Blanche Seagrass Meadowsmentioning

confidence: 99%

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Chelonia mydas fibropapillomatosis in Baie Blanche, Tintamarre Island Saint Martin (FWI), an environmental sciences and veterinary cross-analysis

Saladin¹

2021

Preprint

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Chelonia mydas’s fibropapillomatosis is a panzootic neoplastic disease that has been affecting the species since 1930’s, starting in Key West Florida USA. Most likely induced by the Chelonian HerpesVirus 5 (ChHV5), fibropapillomatosis has been recorded as affecting all species of marine turtles, provoking the growth of malignant external and internal round shaped tumors to marine turtles, that share numerous genomic similarities with human cancers. This research focuses on the two pristine bays of Tintamarre island in Saint Martin (French West Indies), Baie Blanche and Lagon, where the early stage of fibropapillomatosis has been observed affecting juvenile Chelonia mydas resident of Tintamarre. The results obtained when cross-analyzing the environmental monitoring and studies performed of Tintamarre island and a veterinary health assessment of Chelonia mydas juvenile and sub-adult marine turtles of Baie Blanche, bring a different perspective to the environmental pressures that may be responsible of the expression of the disease in Chelonia mydas. Macro-algae and Cadmium (Cd) contamination of marine turtles habitat and foraging grounds are environmental parameters that are found as possibly inducing fibropapillomatosis clinical expression in Tintamarre in this research, concurring with previous publications findings. Tintamarre island in Saint Martin (FWI) is a key site to study pertaining to marine turtle fibropapillomatosis.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 86%

Section: Studies Of Baie Blanche Seagrass Meadowsmentioning

confidence: 99%

Section: Studies Of Baie Blanche Seagrass Meadowsmentioning

confidence: 99%

See 2 more Smart Citations

Chelonia mydas fibropapillomatosis in Baie Blanche, Tintamarre Island Saint Martin (FWI), an environmental sciences and veterinary cross-analysis

Saladin¹

2021

Preprint

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“…For most trace metals, metabolism is usually not considered due to the lack of biotransformation in animals (Dogruer et al, 2021;O'Flaherty, 1995). However, there are some exceptions.…”

Section: Application Of Pbk Modelling To Facilitate Qivivementioning

confidence: 99%

Modulatory effects of divalent mercury and lead on the immune responses of waterfowl upon a viral-like immune challenge

Han¹

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Block the pathogens from entering the body, trap, washout and kill pathogesChapter 1 20 1 exposure on cytotoxicity, oxidative stress, immune gene expression and cytokine production are presented. These data provide more insights in cellular mechanisms and effects on specific immune cell types.Chapter 6 discusses the findings of the studies within the current scientific framework and presents future outlooks.Chapter 7 provides a summary of the whole thesis.

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Recommendation of consensus definition of sea turtle fibropapillomatosis

Saladin,

Freggi

2024

Wildlife Letters

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Sea turtle fibropapillomatosis (FP) is an emerging transboundary contagious disease that affected concomitantly two different marine hot spots in the Northern Atlantic Ocean and in the South China Sea at the beginning of the twentieth century. FP reached a panzootic status in the 1990s in green turtle (Chelonia mydas) populations, with increased risks of emergence and spread of the disease which have been correlated with climate induced terrestrial and oceanic physical and chemical changes. During 2023–2024, scientific experts performed a bibliographic review and recommend the consensus definition of sea turtle fibropapillomatosis. FP is an emerging transboundary viral terrestrial and aquatic contagious neoplastic syndrome involving cancerous molecular transmission pathways, which may affect all species of sea turtles at all life stages. The diagnosis of the most common verrucous form of FP is pathognomonic by visual examination of a sea turtle. We summarize the main clinical characteristics of FP, moderated by a degree of confidence of research findings adapted from the Intergovernmental Panel on Climate Change (IPCC) assessment reports. We recommend the implementation of a universal and transparent monitoring strategy of sea turtle fibropapillomatosis in sentinel bays, under the governance of the World Organisation for Animal Health.

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An integrative approach to define chemical exposure threshold limits for endangered sea turtles

Cited by 6 publications

References 44 publications

Chelonia mydas fibropapillomatosis in Baie Blanche, Tintamarre Island Saint Martin (FWI), an environmental sciences and veterinary cross-analysis

Chelonia mydas fibropapillomatosis in Baie Blanche, Tintamarre Island Saint Martin (FWI), an environmental sciences and veterinary cross-analysis

Modulatory effects of divalent mercury and lead on the immune responses of waterfowl upon a viral-like immune challenge

Recommendation of consensus definition of sea turtle fibropapillomatosis

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