An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)

Liu, Xuanyou; Wu, Hao; Liu, Zhenguo

doi:10.3390/cancers14112658

Cited by 25 publications

(18 citation statements)

References 76 publications

(85 reference statements)

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“…During the G2/M phase and mitosis, CDK1 is essential to regulate cell division. In a variety of cancers, overexpression of CDK1 can also promote their development and progression [42]. It has already been con rmed that CDK1 is associated with cellular mobility and proliferation, and it is downregulated with THRIL overexpression [43].…”

Section: Discussionmentioning

confidence: 99%

Screening of a potential bioinformatics-based biomarker in keloid and its correlation with immune infiltration

Zhang

Dong

et al. 2023

Preprint

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Keloid is a pathological result caused by cutaneous injury and irritation, which is on account of excessive deposition of collagen matrix and the growth of fibrous tissue. Long term and uncontrolled chronic inflammation is also one of the main causes. The mechanism of its formation is not clear. Therefore, in this study, we aimed to find key genes for diagnosis. We selected two datasets from the GEO database to find DGEs. Then, we finally obtained one gene, HOXC9, via WGCNA analysis and two algorithms (LASSO and SVM-RFE). Next, we analyzed its expression in normal tissues versus keloid and studied its change over time by Mfuzz time clustering analysis. Finally, through the analysis of this gene and previous studies we realized that, in addition to cell proliferation, immune infiltration also plays a role during the process of keloid formation, and we then explored the infiltration of immune cells in the normal versus keloid groups and the relationship between this gene and them.

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Section: Discussionmentioning

confidence: 99%

Screening of a potential bioinformatics-based biomarker in keloid and its correlation with immune infiltration

Zhang

Dong

et al. 2023

Preprint

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“…Recently, the cell cycle-independent function of CDK1 in enhancing overall protein synthesis has been uncovered [51]. An integrative human pan-cancer analysis showed that dysregulation of CDK1 was identified in more than 20 human tumors and was significantly correlated with the development, progression, and microenvironment of tumor cells [52]. Lowdose radiation exposure alters the expression of CDK1, which is associated with post-Chernobyl PTC development [53].…”

Section: Discussionmentioning

confidence: 99%

Construction of a novel cuproptosis-related gene signature for predicting prognosis and estimating tumor immune microenvironment status in papillary thyroid carcinoma

et al. 2022

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Background Cuproptosis, a new form of programmed cell death, has been recently reported to be closely related to tumor progression. However, the significance of cuproptosis-related genes (CRGs) in papillary thyroid carcinoma (PTC) is still unclear. Therefore, this study aimed to investigate the role of the CRG signature in prognosis prediction and immunotherapeutic effect estimation in patients with PTC. Methods RNA-seq data and the corresponding clinical information of patients with PTC were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Comprehensive analyses, namely, consensus clustering, immune analyses, functional enrichment, least absolute shrinkage and selection operator-multivariate Cox regression, and nomogram analysis, were performed to identify new molecular subgroups, determine the tumor immune microenvironment (TIME) status of the identified subgroups, and construct a clinical model. Independent verification cohort data and quantitative real-time polymerase chain reaction (qPCR) was performed to validate the expression of specific prognosis-related and differentially expressed CRGs (P-DECRGs). Results In the TCGA database, 476 patients with PTC who had complete clinical and follow-up information were included. Among 135 CRGs, 21 were identified as P-DECRGs. Two molecular subgroups with significantly different disease-free survival and TIME statuses were identified based on these 21 P-DECRGs. The differentially expressed genes between the two subgroups were mainly associated with immune regulation. The risk model and nomogram were constructed based on four specific P-DECRGs and validated as accurate prognostic predictions and TIME status estimation for PTC by TCGA and GEO verification cohorts. Finally, the qPCR results of 20 PTC and paracancerous thyroid tissues validated those in the TCGA database. Conclusions Four specific P-DECRGs in PTC were identified, and a clinical model based on them was established, which may be helpful for individualized immunotherapeutic strategies and prognostic prediction in patients with PTC.

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“…Its dysregulation is common in many tumors of diverse origins, leading to chromosomal instability via replication stress and enhanced proliferation of cells. A recent pan-cancer integrative analysis based on TCGA and GTEx databases performed by Liu et al (2022) showed that CDK1 expression levels are increased in many tumor types when compared to normal tissues and are generally associated with poor clinical prognosis [ 336 ]. For example, CDK1 expression is positively and highly associated with advanced cancer stages in lung and endometrial cancer [ 337 , 338 ].…”

Section: Protein Kinases In Pediatric Oncology and Their Association ...mentioning

confidence: 99%

Drugging Hijacked Kinase Pathways in Pediatric Oncology: Opportunities and Current Scenario

et al. 2023

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Childhood cancer is considered rare, corresponding to ~3% of all malignant neoplasms in the human population. The World Health Organization (WHO) reports a universal occurrence of more than 15 cases per 100,000 inhabitants around the globe, and despite improvements in diagnosis, treatment and supportive care, one child dies of cancer every 3 min. Consequently, more efficient, selective and affordable therapeutics are still needed in order to improve outcomes and avoid long-term sequelae. Alterations in kinases’ functionality is a trademark of cancer and the concept of exploiting them as drug targets has burgeoned in academia and in the pharmaceutical industry of the 21st century. Consequently, an increasing plethora of inhibitors has emerged. In the present study, the expression patterns of a selected group of kinases (including tyrosine receptors, members of the PI3K/AKT/mTOR and MAPK pathways, coordinators of cell cycle progression, and chromosome segregation) and their correlation with clinical outcomes in pediatric solid tumors were accessed through the R2: Genomics Analysis and Visualization Platform and by a thorough search of published literature. To further illustrate the importance of kinase dysregulation in the pathophysiology of pediatric cancer, we analyzed the vulnerability of different cancer cell lines against their inhibition through the Cancer Dependency Map portal, and performed a search for kinase-targeted compounds with approval and clinical applicability through the CanSAR knowledgebase. Finally, we provide a detailed literature review of a considerable set of small molecules that mitigate kinase activity under experimental testing and clinical trials for the treatment of pediatric tumors, while discuss critical challenges that must be overcome before translation into clinical options, including the absence of compounds designed specifically for childhood tumors which often show differential mutational burdens, intrinsic and acquired resistance, lack of selectivity and adverse effects on a growing organism.

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An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)

Cited by 25 publications

References 76 publications

Screening of a potential bioinformatics-based biomarker in keloid and its correlation with immune infiltration

Screening of a potential bioinformatics-based biomarker in keloid and its correlation with immune infiltration

Construction of a novel cuproptosis-related gene signature for predicting prognosis and estimating tumor immune microenvironment status in papillary thyroid carcinoma

Drugging Hijacked Kinase Pathways in Pediatric Oncology: Opportunities and Current Scenario

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