2017
DOI: 10.1101/147868
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An integrative method to unravel the host-parasite interactome: an orthology-based approach

Abstract: The study of molecular host-parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require clear understanding of the molecular crosstalk between parasites and their hosts. As yet, experimental large-scale identification of host-parasite molecular interactions remains challenging and the use of in silico predictions becomes then necessary. Here, we propose a computational integrative approach to predic… Show more

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Cited by 3 publications
(2 citation statements)
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References 86 publications
(96 reference statements)
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“…All the experimentally determined HP-PPIs related to the human host and all pathogens were gathered, housed in several HPI databases: Reactome [ 52 ], HMDAD [ 53 ], PHI-base [ 54 ], OrthoHPI [ 55 ], VirusMINT [ 56 ], MatrixDB [ 57 ], BioGrid [ 58 ], HPIDb [ 59 ], MINT [ 60 ], IMEx [ 61 ], IntAct [ 62 ], UniProt [ 63 ], MPIDB [ 64 ], VirHostNet [ 65 ], I2D [ 66 ], InnateDB [ 67 ], DIP [ 68 ] and PHISTO [ 69 ]. These databases are exclusively dedicated for HPIs, however, there are some other databases that serve as data repositories to search and collect protein/gene interaction data, provide the information of PPIs of a single host [ 70 ].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…All the experimentally determined HP-PPIs related to the human host and all pathogens were gathered, housed in several HPI databases: Reactome [ 52 ], HMDAD [ 53 ], PHI-base [ 54 ], OrthoHPI [ 55 ], VirusMINT [ 56 ], MatrixDB [ 57 ], BioGrid [ 58 ], HPIDb [ 59 ], MINT [ 60 ], IMEx [ 61 ], IntAct [ 62 ], UniProt [ 63 ], MPIDB [ 64 ], VirHostNet [ 65 ], I2D [ 66 ], InnateDB [ 67 ], DIP [ 68 ] and PHISTO [ 69 ]. These databases are exclusively dedicated for HPIs, however, there are some other databases that serve as data repositories to search and collect protein/gene interaction data, provide the information of PPIs of a single host [ 70 ].…”
Section: Methodsmentioning
confidence: 99%
“…All the experimentally determined HP-PPIs related to the human host and all pathogens were gathered, housed in several HPI databases: Reactome [52], HMDAD [53], PHI-base [54], OrthoHPI [55], VirusMINT [56], MatrixDB [57], BioGrid [58], HPIDb [59], MINT [60], IMEx [61], IntAct [62], UniProt [63], MPIDB [64], VirHostNet [65], I2D [66], InnateDB [67], DIP [68] and PHISTO [69].…”
Section: Network Constructionmentioning
confidence: 99%