The purpose of this study was to assess the perceived self‐efficacy toward adult inpatient violence and the quality of professional life status among mental health nurses. The study was conducted in mental health and psychiatric hospitals in Central Region in Saudi Arabia. The study used cross‐sectional, descriptive, and quantitative approaches. Data were collected by self‐administrative, and five Likert‐scaled questionnaires. The study findings revealed that there was a positive relationship between the nurses’ perceived self‐efficacy and quality of professional life. Also, the study findings declared that there were no statistically significant differences between self‐efficacy in the theme of gender, qualification, and experience‐associated demographic factors. The study recommended that mental health nursing staff receive additional training on violence and self‐efficacy to deal with workplace violence. Moreover, the study recommended carrying out studies on a wide range to investigate the factors behind aggression and violence. Also, the study recommended a rigorous review for nurses’ policy toward violence management.