An integrative review on the uses of plant-derived bioactives formulated in conventional and innovative dosage forms for the local treatment of damaged nasal cavity

Casula, Eleonora; Manca, Maria Letizia; Manconi, Maria

doi:10.1016/j.ijpharm.2021.121229

Cited by 9 publications

(3 citation statements)

References 147 publications

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“…A significant number of chemical compounds derived from plants are considered to be potential pharmaceutical sources for the treatment of various diseases [5][6][7][8]. For drug development, bioactive compounds originating from plants, such as flavonoids, tannins, polyphenols and alkaloids, play vital roles.…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals, Antioxidant and Antidiabetic Activities of Extracts from Miliusa velutina Flowers

et al. 2021

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The flowers of M. velutina were extracted with ethanol to obtain a crude extract that was consecutively extracted using n-hexane, dichloromethane, ethyl acetate and water. The crude extract and fractions were studied for the chemical composition and antioxidant and antidiabetic activities. The extracts had various phytoconstituents, namely steroids, flavonoids, tannins, saponins, alkaloids and glycosides. The aqueous extract had the highest total polyphenol (12.6 mg GAE/g extract) and total flavonoid (205.6 mg QE/g extract) content. The aqueous extract exhibited the strongest antioxidant activities in the ferric reducing antioxidant power assay (EC50 = 4.0 µg/mL), reducing power assay (EC50 = 78.1 µg/mL), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid radical cation assay (EC50 = 48.2 µg/mL), total antioxidant capacity assay (EC50 = 8.7 µg/mL) and 1,1-diphenyl-2-picrylhydrazyl assay (EC50 = 9.3 µg/mL). The aqueous extract showed the strongest inhibitory effect on the activity of α-amylase (IC50 = 376.6 μg/mL) and α-glucosidase (IC50 = 69.7 μg/mL). The results showed that the aqueous extract of M. velutina flowers can be a promising candidate for the control of diabetes and oxidative stress. This is the first report about the chemical components and antioxidant and antidiabetic activities of M. velutina flower extracts.

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Section: Introductionmentioning

confidence: 99%

Phytochemicals, Antioxidant and Antidiabetic Activities of Extracts from Miliusa velutina Flowers

et al. 2021

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“…Consumers trust phytochemicals more than synthetic drugs. 1 The development of new drugs from phytochemicals has grown in popularity in recent decades. Eight phytochemical-based drugs have already been approved by the US FDA, including glycyrrhizin.…”

Section: Introductionmentioning

confidence: 99%

Novel pterostilbene-loaded pro-phytomicelles: preclinical pharmacokinetics, distribution, and treatment efficacy against acetaminophen-induced liver injury

et al. 2022

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“…However, many factors may contribute to its onset, such as environmental factors (temperature, humidity, and air pollution) and the host’s general condition (anatomical variants, allergies, local or systemic immune system imbalance, and genetic predisposition) [ 4 , 5 ]. Medical treatment mainly uses local corticosteroids, nasal irrigation, and antibiotics; however, there is a scarcity of information in the literature about the use of nasal spray medical formulations for local treatment of CRS [ 6 ]. If medical treatment is insufficient, endoscopic sinus surgery is proposed.…”

Section: Introductionmentioning

confidence: 99%

The Role of Probiotics in Chronic Rhinosinusitis Treatment: An Update of the Current Literature

et al. 2021

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Chronic rhinosinusitis (CRS) is a significant health problem. It affects 5–12% of the general population. The causes that underlie the onset of CRS are not yet well known. However, many factors may contribute to its onset, such as environmental factors and the host’s general condition. Medical treatment mainly uses local corticosteroids, nasal irrigation, and antibiotics. In recent years, a new therapeutic approach that employs the use of probiotics emerged. Probiotics have been extensively studied as a therapy for dysbiosis and inflammatory pathologies of various parts of the body. We aimed to examine the studies in vivo and in vitro and clinicals reports in the existing literature to update probiotics’ role in rhinosinusitis chronic medical treatment.

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An integrative review on the uses of plant-derived bioactives formulated in conventional and innovative dosage forms for the local treatment of damaged nasal cavity

Cited by 9 publications

References 147 publications

Phytochemicals, Antioxidant and Antidiabetic Activities of Extracts from Miliusa velutina Flowers

Phytochemicals, Antioxidant and Antidiabetic Activities of Extracts from Miliusa velutina Flowers

Novel pterostilbene-loaded pro-phytomicelles: preclinical pharmacokinetics, distribution, and treatment efficacy against acetaminophen-induced liver injury

The Role of Probiotics in Chronic Rhinosinusitis Treatment: An Update of the Current Literature

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