Due to their simplicity and relative ease of manufacture, single-stage centrifugal and mixed flow micro gas turbine (MGT) engines are preferred in thrust-based remotely piloted aerial vehicles. A single-stage mixed-flow compressor upgrade for the 200 N CAT250TJ MGT engine is numerically evaluated and presented. An in-house developed mean line application and commercial CFD software is used for the design and performance evaluation of the proposed upgrade configurations. The CAT250TJ – Gen1 engine features a single-stage centrifugal compressor, annular combustor, and single stage axial turbine. Apart from an upgraded impeller, a new crossover diffuser configuration is introduced to replace the wedge-type, straight outlet diffuser configuration of the Gen1 engine. The new single vane crossover diffuser configuration provides a design point total-to-total efficiency and pressure ratio increase of 8.3% and 12.1%, respectively. A disadvantage of a single-vaned crossover diffuser compared to legacy diffusers is a narrower operating range. To alleviate this issue, various combinations of tandem and splitter vane crossover diffuser configurations are proposed. These provide an enhanced operating range, comparable with the operating range displayed by the Gen1 configuration. A turbine power matching analysis is additionally completed to ensure proper compressor integration. Gas turbine cycle software is used to evaluate the on-engine performance of the upgraded compressor configurations. It is shown that the new baseline, single vane crossover diffuser configuration provides a 10.74% increase in design point static thrust.