An interactive database of Leishmania species distribution in the Americas

Herrera, Giovanny; Barragán, Natalia; Luna, Nicolás; Martinez, David R.; Martino, Frasella De; Medina, Julián; Niño, Sergio; Páez, Luisa; Ramírez, Angie; Vega, Laura; Velandia, Valeria; Vera, Michelle; Zúñiga, María Fernanda Chaves; Bottin, Marius; Ramírez, Juan David

doi:10.1038/s41597-020-0451-5

Cited by 50 publications

(46 citation statements)

References 18 publications

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“…2 Public health interventions to reduce the impact of VL require strengthening public health surveillance, vector control activities, and social improvements. 3–8…”

Section: Discussionmentioning

confidence: 99%

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Visceral leishmaniasis in the island of Margarita, Venezuela: a neglected parasitic infection in the Caribbean

Oronoz

Pedraza-Arévalo

Henao‐Martínez

et al. 2021

Therapeutic Advances in Infection

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Visceral leishmaniasis carries a significant burden of disease in the Americas with up to 7000 cases reported annually. There are several reports of autochthonous visceral leishmaniasis cases in the Caribbean, including the Dominican Republic, Guadalupe, Martinique, and Trinidad and Tobago. However, we lack recent clinical description and epidemiologic data of visceral leishmaniasis in other islands in the Caribbean. Herein, we describe an autochthonous case of visceral leishmaniasis in the Caribbean Island of Margarita in Venezuela. This index case of visceral leishmaniasis highlights the need for further regional surveillance efforts to identify animal reservoirs and to monitor the occurrence of further clinical cases. Additionally, there is an urgent need for implementing vector control strategies.

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“…2 Public health interventions to reduce the impact of VL require strengthening public health surveillance, vector control activities, and social improvements. 3–8…”

Section: Discussionmentioning

confidence: 99%

“…Most VL cases in Venezuela are reported among coastal towns. 4 In previous decades, the island of Margarita contributed to some of the overall number of cases in the region. The first report of VL in Margarita Island was in 1965.…”

Section: Introductionmentioning

confidence: 99%

Visceral leishmaniasis in the island of Margarita, Venezuela: a neglected parasitic infection in the Caribbean

Oronoz

Pedraza-Arévalo

Henao‐Martínez

et al. 2021

Therapeutic Advances in Infection

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“…Leishmaniasis is a parasitic disease that is non-endemic to Cuba, although a few imported cases have been documented [58]. However, leishmaniasis is considered to be one of the most important tropical diseases by the World Health Organization (WHO) and presents high importance in the Americas due to an elevated number of leishmaniasis cases (accounting for two-thirds of the worldwide disease burden) and circulating Leishmania species [59].…”

Section: Chemical and Pharmacological Overview Of Essential Oil From Cuban Plantsmentioning

confidence: 99%

Bioactive Essential Oils from Cuban Plants: An Inspiration to Drug Development

Monzote

Díaz

González

et al. 2021

Plants

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Aromatic plants and essential oils are important agents as complementary and alternative medicines in many cultures and geographical locations. In this review, a literature search on essential oils from Cuba, their chemical compositions, and their pharmacological properties was carried out. Out of 171 published scientific articles on essential oils of Cuban plants, a total of 31 documents, focused on both chemical composition and pharmacological properties, were considered for this review. In general, an increase in articles published in the last decade was noted, particularly in recognized international journals in English. Myrtaceae and Piperaceae were the most representative families collected in the occidental area of the country. Leaves and aerial parts were predominantly used, while a wide and variable number of components were identified, including terpenes, aliphatic derivatives, sulfur-containing compounds, phenylpropanoids, alkaloids and amine-type compounds. Finally, different biological activities were reported such as antiprotozoal, antibacterial, antifungal, cytotoxic, anthelmintic, larvicidal and insecticidal. In conclusion, we encourage further studies that would promote the use of essential oils from Cuban plants in new pharmaceutical products.

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“…Recent surveys indicate that approximately 350 million people live in a vulnerable situation with the risk of contracting leishmaniasis. From a global perspective, the disease currently affects approximately 12–15 million people worldwide [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?

et al. 2021

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Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12–15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed.

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An interactive database of Leishmania species distribution in the Americas

Cited by 50 publications

References 18 publications

Visceral leishmaniasis in the island of Margarita, Venezuela: a neglected parasitic infection in the Caribbean

Visceral leishmaniasis in the island of Margarita, Venezuela: a neglected parasitic infection in the Caribbean

Bioactive Essential Oils from Cuban Plants: An Inspiration to Drug Development

Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?

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