An interactome analysis reveals that Arabidopsis thaliana GRDP2 interacts with proteins involved in post-transcriptional processes

Castro-Bustos, Saraí; Maruri-López, Israel; Ortega-Amaro, María Azucena; Serrano, Mario; Ovando-Vázquez, Cesaré; Jiménez-Bremont, Juan Francisco

doi:10.1007/s12192-022-01261-5

Cited by 2 publications

(2 citation statements)

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“…Glycine-enrich RNA-binding proteins (GR-RBPs) are central players in post-transcriptional regulation, and their functions have been extensively studied in the model plant Arabidopsis thaliana [8,45,111,112]. GR-RBPs regulate gene expression and cell fate through various RNA processing mechanisms, including alternative splicing, polyadenylation, editing, as well as RNA transport, stabilization, translation, and degradation.…”

Section: Discussionmentioning

confidence: 99%

“…RNAbinding proteins are strategically located within various cellular compartments to carry out specific functions, ensuring proper cellular functioning. For instance, AtGRDP2 interacts with proteins involved in RNA processing and translation in different compartments: it associates with PABN3 in the nucleus, EF-1α in the cytosol, and CL15 in chloroplasts [8]. While the functional roles of various RBPs in living organisms have been elucidated over the past few decades, it is evident that the functional roles of RBPs in plants still remain significantly underdeveloped [9].…”

Section: Introductionmentioning

confidence: 99%

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The Glycine-Rich RNA-Binding Protein Is a Vital Post-Transcriptional Regulator in Crops

Cheng,

Zhang,

et al. 2023

Plants

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Glycine-rich RNA binding proteins (GR-RBPs), a branch of RNA binding proteins (RBPs), play integral roles in regulating various aspects of RNA metabolism regulation, such as RNA processing, transport, localization, translation, and stability, and ultimately regulate gene expression and cell fate. However, our current understanding of GR-RBPs has predominantly been centered on Arabidopsis thaliana, a model plant for investigating plant growth and development. Nonetheless, an increasing body of literature has emerged in recent years, shedding light on the presence and functions of GRPs in diverse crop species. In this review, we not only delineate the distinctive structural domains of plant GR-RBPs but also elucidate several contemporary mechanisms of GR-RBPs in the post-transcriptional regulation of RNA. These mechanisms encompass intricate processes, including RNA alternative splicing, polyadenylation, miRNA biogenesis, phase separation, and RNA translation. Furthermore, we offer an exhaustive synthesis of the diverse roles that GR-RBPs fulfill within crop plants. Our overarching objective is to provide researchers and practitioners in the field of agricultural genetics with valuable insights that may inform and guide the application of plant genetic engineering for enhanced crop development and sustainable agriculture.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%