An interethnic comparison of the distribution of vitamin D receptor genotypes and haplotypes

Rezende, Vania B.; Barbosa, Fernando; Montenegro, Marcelo F.; Sandrim, Valéria C.; Gerlach, Raquel Fernanda; Tanus‐Santos, José Eduardo

doi:10.1016/j.cca.2007.05.010

Cited by 27 publications

(20 citation statements)

References 21 publications

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“…In fact, there is evidence that VDR polymorphisms are not equally distributed in different populations [26]. Therefore other studies examining the possible association between VDR polymorphisms and hypertensive disorders of pregnancy should be carried our in other populations.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

et al. 2012

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Hypertension is the most common medical disorder in pregnancy, and a leading cause of maternal and neonatal morbidity and mortality. Vitamin D endocrine system has important influence on immune modulation and endothelial function, which play a role in preeclampsia (PE) and gestational hypertension (GH). Vitamin D receptor (VDR) is present in a large variety of cell types, including placental cells. We examined whether there is an association between VDR polymorphisms (FokI, ApaI and BsmI) with PE or with GH. Restriction fragment length polymorphism techniques were used to genotype 529 pregnant (154 with GH, 162 with PE, and 213 healthy pregnant-HP). VDR haplotype frequencies were inferred using the PHASE 2.1 program. We found similar genotype distributions for the three VDR polymorphisms in both PE and GH groups compared with the HP group (all P [ 0.05). In parallel with these findings, the VDR haplotype frequency distribution was similar in both PE and GH groups compared with the HP group (all P [ 0.05). Our results showing no significant association between VDR polymorphisms or haplotypes with PE or GH suggest that genetic variations in VDR do not predispose to hypertensive disorders of pregnancy.

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Section: Discussionmentioning

confidence: 99%

“…Genotypes for the Fok I, ApaI and BsmI were determined by restriction fragment length polymorphism techniques as previously described [26,27].…”

Section: Genotypingmentioning

confidence: 99%

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

et al. 2012

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“…T2DM is a multifactorial metabolic disorder, influenced by both genetic and environmental factors and exhibits a wide range of disparities among different ethnic groups12345. The identification of genes predisposing to T2DM could provide means to better understand the pathogenesis of the disease and result in better prevention and treatment.…”

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confidence: 99%

Lack of association between FokI polymorphism in vitamin D receptor gene (VDR) & type 2 diabetes mellitus in the Tunisian population

Mahjoubi¹,

Kallel²,

Sbai³

et al. 2016

Indian Journal of Medical Research

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Background & objectives:The impact of several environmental and genetic factors on diabetes is well documented. Though the association between the vitamin D receptor (VDR) gene polymorphisms and type 2 diabetes mellitus (T2DM) has been analyzed in different ethnic groups, the results have been inconsistent. The aim of this study was to evaluate the possible association between VDR FokI polymorphism and genetic susceptibility to T2DM in Tunisian population.Methods:A total of 439 unrelated patients with T2DM and 302 healthy controls were included in the study. Genomic DNA was extracted from blood and genotyped for the single nucleotide polymorphism (SNP) of FokI (T/C: (rs2228570) by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis.Results:The genotype distribution and the relative allelic frequencies for the FokI polymorphism were not significantly different between T2DM and controls: in T2DM patients the frequencies of the CC, CT, and TT genotypes were 52.6, 41.0, and 6.1 per cent, respectively, and in controls the genotype frequencies were 55.6, 38.7, and 5.6 per cent, respectively. In our study, the TT genotype of the FokI polymorphism was not associated with T2DM (OR =1.19, 95% CI 0.63 - 2.25, P=0.577).Interpretation & conclusions:Our study showed no significant association of the FokI polymorphism in the vitamin D receptor gene with type 2 diabetes mellitus in Tunisian population.

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“…According to Rezende et al [20], the amplification was carried out using 0.5 μg DNA and 0.2 μM of each primer. The amplification was performed under the following conditions: initial denaturation at 95°C for 3 min, followed by 35 cycles (94°C for 1 min, 69°C for 30 s, and 72°C for 30 s) then final extension at 72°C for 3 min.…”

Section: Analysis Of Foki Polymorphism (Rs 10735810)mentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and breast cancer risk among postmenopausal Egyptian women

2015

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Many studies reported that vitamin D can protect against various types of cancers. The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR). VDR may have anti-stress function because it has been identified as p53 direct target gene. This research was designed to investigate the role of VDR polymorphisms BsmI (rs 1544410), ApaI (rs 7975232), TaqI (rs 731236), and FokI (rs 10735810) in pathogenesis of breast cancer using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The study included 130 postmenopausal breast cancer cases aged 49 to 65 years and 100 controls aged 50 to 72 years. A significantly increased risk of breast cancer among carriers of BsmI bb genotype was observed (OR = 2.5 (1.1-5.6), P = 0.025). Also, a significantly increased risk of breast cancer was detected among women carrying ApaI aa genotype (OR = 2.2 (1.02-4.5), P = 0.04), while no significant associations were observed between breast cancer risk and genotypes and allele frequencies of FokI and TaqI polymorphisms (P > 0.05). Our study showed that VDR gene polymorphisms (BsmI and ApaI) may contribute to breast cancer risk among postmenopausal women.

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An interethnic comparison of the distribution of vitamin D receptor genotypes and haplotypes

Cited by 27 publications

References 21 publications

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

Lack of association between FokI polymorphism in vitamin D receptor gene (VDR) & type 2 diabetes mellitus in the Tunisian population

Vitamin D receptor gene polymorphisms and breast cancer risk among postmenopausal Egyptian women

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