Multi-hop wireless networks are designed to support long-distance, cost-effective communication with high data transfer rate. Maximizing network throughput is one of the critical goals while developing a multi-hop wireless network. Efficient routing and scheduling techniques enhance throughput and reduce delay, which improves the overall network performance. This paper proposes a transmission group-based routing and scheduling (𝑇𝐺𝑅𝑆) technique implemented in centralized and distributed ways. The main aim of this study is to enhance the performance of 3D multi-hop wireless networks in terms of throughput and delay. Users establish a routing path to the base station based on the minimum angle-based IM selection process. In 𝑇𝐺𝑅𝑆, multiple groups are formed for all the IM links of the routing path; links are included in the same group if they do not interfere mutually. All the links of a group are transmitted concurrently, which maximizes throughput and minimizes delay. The proposed 𝑇𝐺𝑅𝑆 technique dramatically improves network performance by increasing concurrent transmission and throughput. The effectiveness of the proposed techniques is demonstrated through extensive simulation.