An interleukin-4-loaded bi-layer 3D printed scaffold promotes osteochondral regeneration

Gong, Lin; Li, Jun; Zhang, Jingwei; Pan, Zongyou; Liu, Yanshan; Zhou, Feifei; Hong, Yi; Hu, Yin; Gu, Yuqing; Ouyang, Hongwei; Zou, Xiaohui; Zhang, Shufang

doi:10.1016/j.actbio.2020.09.039

Cited by 79 publications

(119 citation statements)

References 73 publications

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“…The combined use of a wide range of pro-osteogenic scaffolds such as decellularized bone matrix, bi-layer hydrogel-porous scaffolds, and calcium-enriched hydrogels [ 129 , 132 , 133 ] loaded with IL-4, a key anti-inflammatory cytokine secreted by M2 macrophages, is now being explored as a promising strategy for repair of bone defects [ 129 , 133 ]. Interestingly, calcium-enriched hydrogels loaded with IL-4 showed superior in vitro and in vivo abilities in inducing both M2 macrophages polarization and MSCs osteogenesis by enhancing TGF-β1/Smad pathway.…”

Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

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Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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“…Bi‐layer porous scaffold, wherein a gelatin methacrylate scaffold printed with digital light processing as the upper layer and a PCL‐HAp scaffold printed with fused deposition modeling as the lower layer, was loaded with IL‐4 into gelatin layer. [ 259 ] This hybrid scaffold reduced inflammation on murine chondrocytes and promoted regeneration of both cartilage and subchondral bone in a rabbit osteochondral defect model. A biomimetic gelatin hydrogel system, which was prepared through “chemical‐curing, shaping, and light‐curing” process, was used for cartilage repair.…”

Section: Tissue Regeneration/repair Regulated With Immunomodulationmentioning

confidence: 99%

Toward a Better Regeneration through Implant‐Mediated Immunomodulation: Harnessing the Immune Responses

Zhang

Zhou

et al. 2021

Advanced Science

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Tissue repair/regeneration, after implantation or injury, involves comprehensive physiological processes wherein immune responses play a crucial role to enable tissue restoration, amidst the immune cells early‐stage response to tissue damages. These cells break down extracellular matrix, clear debris, and secret cytokines to orchestrate regeneration. However, the immune response can also lead to abnormal tissue healing or scar formation if not well directed. This review first introduces the general immune response post injury, with focus on the major immune cells including neutrophils, macrophages, and T cells. Next, a variety of implant‐mediated immunomodulation strategies to regulate immune response through physical, chemical, and biological cues are discussed. At last, various scaffold‐facilitated regenerations of different tissue types, such as, bone, cartilage, blood vessel, and nerve system, by harnessing the immunomodulation are presented. Therefore, the most recent data in biomaterials and immunomodulation is presented here in a bid to shape expert perspectives, inspire researchers to go in new directions, and drive development of future strategies focusing on targeted, sequential, and dynamic immunomodulation elicited by implants.

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“…In the earlier stage of FDM, the printing potential was limited by a small selection of thermoplastic filament materials [ 61 ]. Fortunately, with an increasing variety of filament materials offering a wide range of physical, mechanical, and electronic properties, FDM is now highly compatible with a wider range of materials, including acrylonitrile butadiene styrene (ABS) [ 62 , 63 , 64 ], polycaprolactone (PCL) [ 65 , 66 , 67 , 68 ], polylactic acid (PLA) [ 69 , 70 , 71 ], nylon [ 72 , 73 , 74 ], polypropylene (PP) [ 75 , 76 , 77 ], thermoplastic polyurethanes (TPU) [ 78 , 79 ], polyvinyl alcohol (PVA) [ 80 , 81 ], high impact polystyrene (HIPS) [ 82 , 83 ], and composite filaments [ 84 ]. Therefore, multi-material 3D printing using FDM has drawn growing interest in recent years.…”

Section: Systematic Review Of Current Researchmentioning

confidence: 99%

Scientometric Analysis and Systematic Review of Multi-Material Additive Manufacturing of Polymers

et al. 2021

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Multi-material additive manufacturing of polymers has experienced a remarkable increase in interest over the last 20 years. This technology can rapidly design and directly fabricate three-dimensional (3D) parts with multiple materials without complicating manufacturing processes. This research aims to obtain a comprehensive and in-depth understanding of the current state of research and reveal challenges and opportunities for future research in the area. To achieve the goal, this study conducts a scientometric analysis and a systematic review of the global research published from 2000 to 2021 on multi-material additive manufacturing of polymers. In the scientometric analysis, a total of 2512 journal papers from the Scopus database were analyzed by evaluating the number of publications, literature coupling, keyword co-occurrence, authorship, and countries/regions activities. By doing so, the main research frame, articles, and topics of this research field were quantitatively determined. Subsequently, an in-depth systematic review is proposed to provide insight into recent advances in multi-material additive manufacturing of polymers in the aspect of technologies and applications, respectively. From the scientometric analysis, a heavy bias was found towards studying materials in this field but also a lack of focus on developing technologies. The future trend is proposed by the systematic review and is discussed in the directions of interfacial bonding strength, printing efficiency, and microscale/nanoscale multi-material 3D printing. This study contributes by providing knowledge for practitioners and researchers to understand the state of the art of multi-material additive manufacturing of polymers and expose its research needs, which can serve both academia and industry.

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An interleukin-4-loaded bi-layer 3D printed scaffold promotes osteochondral regeneration

Cited by 79 publications

References 73 publications

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Toward a Better Regeneration through Implant‐Mediated Immunomodulation: Harnessing the Immune Responses

Scientometric Analysis and Systematic Review of Multi-Material Additive Manufacturing of Polymers

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