An international multicentre evaluation of treatment strategies for combined hepatocellular-cholangiocarcinoma✰

Claasen, Marco; Ivanics, Tommy; Beumer, Berend R.; Wilde, Roeland F. de; Polak, Wojciech; IJzermans, Jan N.M.

doi:10.1016/j.jhepr.2023.100745

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…In this line, it is noteworthy that, despite its missing implementation into daily clinical routine, LT for cHCC-CCA is already considered a reasonable therapeutic approach for selected individuals. In a recent international multicenter evaluation of treatment strategies for cHCC-CCA among members of the European Network for the Study of Cholangiocarcinoma (ENS-CCA) and the International Cholangiocarcinoma Research Network (ICRN), 59 % of clinicians considered LT as a therapeutic option for patients with biopsy-proven cHCC-CCA (surgeons: 64 %, hepatologists/gastroenterologists: 55 %, and oncologists: 56 %) [76]. Most clinicians accepted a single lesion size of 5 cm (49 %) and a combination of three lesions with a maximum largest lesion size of 3 cm (64 %) as a potential size limit, and the majority of clinicians (55 %) would consider LT only in patients with well-differentiated tumors [76].…”

Section: Intrahepatic Cholangiocarcinomamentioning

confidence: 99%

Liver transplantation meets gastrointestinal cancer

Loosen,

Leyh,

Neumann

et al. 2024

Z Gastroenterol

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Liver transplantation (LT) has emerged as a standard of care for patients with end-stage liver disease, providing a life-saving intervention for patients with severely compromised liver function in both the acute and chronic setting. While LT has also become a routine procedure for early-stage hepatocellular carcinoma (HCC), offering a potential cure by treating both the tumor and the underlying liver disease, its relevance in the context of other malignancies such as cholangiocellular carcinoma (CCA), combined hepatocellular-cholangiocarcinoma (cHCC-CCA) or liver metastases is still the subject of intense debate and no definite recommendations have yet been established. This review summarizes the current therapeutic standards in the context of LT for gastrointestinal malignancies and provides a reflection and outlook on current scientific and clinical developments.

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Section: Intrahepatic Cholangiocarcinomamentioning

confidence: 99%

Liver transplantation meets gastrointestinal cancer

Loosen,

Leyh,

Neumann

et al. 2024

Z Gastroenterol

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“…No tients' understanding of the procedure, postoperative rehabilitation and discomfort, thereby reducing fear of the unknown [15]. Through early information transmission and emotional guidance, patients are taught negative emotion regulation, so that patients can more fully prepare themselves and reduce fear of the unknown, thereby reducing preoperative stress perception Secondly, psychological support groups offer additional emotional support post-surgery through various psychological support pathways, aiding patients in managing mood swings [16,17]. Li Q et al [18] reported the effectiveness of psychological intervention combined with body position management, involving psychologists, nursing staff and other healthcare team members, in providing comprehensive patient support and reducing the perception of surgical stress [19].…”

Section: Groupsmentioning

confidence: 99%

Observation on the effect of sequential psychological intervention combined with body position management in patients with primary liver cancer undergoing hepatic arterial infusion chemotherapy

2024

JOMH

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This study aims to observe the effect of sequential psychological intervention combined with body position management on patients diagnosed with primary liver cancer undergoing hepatic arterial infusion chemotherapy (HAIC). A cohort of 108 male patients diagnosed with primary hepatocellular carcinoma, undergoing HAIC at the Department of Oncology in our hospital between February 2022 and January 2024, were retrospectively selected. Patients admitted between February 2022 and January 2023 were included in the control group, while patients admitted between February 2023 and January 2024 were included in the observation group. The control group was treated with routine care, and the observation group received sequential psychological intervention combined with body position management. We compared their psychological status, perceived stress levels, incidence of adverse reactions, and overall comfort levels between the two groups before and after nursing interventions. After nursing interventions, the scores across all dimensions of the Depression Anxiety and Stress Scale (DASS-21) were lower in both the intervention and control groups compared to baseline, with the observation group demonstrating significantly lower scores in the perceived stress scale ((12.11 ± 3.20) points) compared to the control group ((17.12 ± 3.39) points) (p < 0.001). Furthermore, there were statistically significant differences observed in the incidence of adverse reactions and comfort between the two groups (p < 0.001). Sequential psychological intervention combined with body position management demonstrated superior nursing efficacy for male patients undergoing HAIC for primary liver cancer, effectively enhanced psychological well-being, mitigated perceived stress and reduced the occurrence of adverse reactions.

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DSN1 Interaction With Centromere‐Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma

Zhou,

Zhang,

Lian

et al. 2024

Molecular Carcinogenesis

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Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. Dosage suppressor of NNF1 (DSN1), a component of the MIS12 kinetochore complex, encodes a kinetochore protein crucial for proper mitotic assembly. The role of DSN1 in HCC remains to be elucidated. In this study, we utilized The Cancer Genome Atlas, the Hepatocellular carcinoma Cell Database, and other databases to analyze DSN1 expression and prognosis in samples from patients with HCC. We investigated the signaling pathways regulated by DSN1 and their implications in HCC. Additionally, we engineered siRNAsiRNA/shRNA/shRNA and overexpression vectors for DSN1 and assessed the specific mechanisms of regulatory pathways of DSN1 in hepatoma cell lines and subcutaneous tumor xenograft model. Our findings revealed that DSN1 expression was significantly upregulated in patients with HCC, correlating with decreased survival rates. Elevated DSN1 expression led to the overproduction of cell cycle‐related proteins through direct interaction with Centromere Protein T. This interaction contributes to chromosomal instability in patients with HCC, resulting in an aberrant cell cycle and fostering the development and progression of HCC. Increased DSN1 expression is pivotal in HCC initiation and progression. Investigating DSN1 offers valuable insights into the pathogenesis, treatment, and prevention of HCC.

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An international multicentre evaluation of treatment strategies for combined hepatocellular-cholangiocarcinoma✰

Cited by 5 publications

References 46 publications

Liver transplantation meets gastrointestinal cancer

Liver transplantation meets gastrointestinal cancer

Observation on the effect of sequential psychological intervention combined with body position management in patients with primary liver cancer undergoing hepatic arterial infusion chemotherapy

DSN1 Interaction With Centromere‐Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma

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