An Intersectional Study of LncRNAs and mRNAs Reveals the Potential Therapeutic Targets of Buyang Huanwu Decoction in Experimental Intracerebral Hemorrhage

Cui, Hanjin; Liu, Tao; Li, Pengfei; Yang, An‐Gang; Zhou, Hongbo; Luo, Jiayou; Hu, En; Wang, Hu; Wang, Yang; Tang, Tao

doi:10.1159/000489547

Cited by 20 publications

(17 citation statements)

References 57 publications

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“…Cui et al [26] identified differentially expressed genes in Buyang Huanwu decoction intracerebral hemorrhage treatment with lncRNA and mRNA microarray technology and verified the results by qRT-PCR. The biological functions and signal transduction pathways of the differentially expressed genes were analyzed and were found to be related to hemoglobin complexes, oxygen transporters, oxygen transporters, and pyruvate metabolism.…”

Section: Application Of Transcriptomics In Chf Researchmentioning

confidence: 94%

Systems biology approaches in the study of Chinese herbal formulae

Cai

Zhou

et al. 2018

Chin Med

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Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biological system and their interactions under specific conditions. The core of systems biology is holistic and systematic research, which is different from the manner of thinking and research of all other branches of biology to date. Chinese herbal formulae (CHF) are the main form of Chinese medicine and are composed of single Chinese herbal medicines (CHMs) with pharmacological and pharmacodynamic compatibility. When single CHMs are combined into CHF, the result is different from the original effect of a single drug and can be better adapted to more diseases with complex symptoms. CHF represent a complex system with multiple components, targets and effects. Therefore, the use of systems biology is conducive to revealing the complex characteristics of CHF. With the rapid development of omics technologies, systems biology has been widely and increasingly applied to the study of the basis of the pharmacological substances, action targets and mechanisms of CHF. To meet the challenges of multiomics synthesis-intensive studies and system dynamics research in CHF, this paper reviews the common techniques of genomics, transcriptomics, proteomics, metabolomics, and metagenomics and their applications in research on CHF.

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Section: Application Of Transcriptomics In Chf Researchmentioning

confidence: 94%

Systems biology approaches in the study of Chinese herbal formulae

Cai

Zhou

et al. 2018

Chin Med

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“…Furthermore, each herb was authenticated by the herbal medicinal botanist, Professor Suiyu Hu, at the Institute of Integrative Medicine of Xiangya Hospital, CSU. The decoction was prepared and subjected to quality control as previously described 26. Finally, the powder was dissolved in distilled water at a concentration of 0.13 g/ml for intragastric administration 26.…”

Section: Methodsmentioning

confidence: 99%

“…The decoction was prepared and subjected to quality control as previously described 26. Finally, the powder was dissolved in distilled water at a concentration of 0.13 g/ml for intragastric administration 26.…”

Section: Methodsmentioning

confidence: 99%

“…Collagenase-induced ICH rat models were important tools for studying ICH and had been used by many researchers 40, 41. ICH was conducted as described in detail previously and sham rats were injected with the same volume of saline 26, 42. For the BYHWD-treated group, ICH rats were administered once daily from 1 to 21 days by intragastric administration.…”

Section: Methodsmentioning

confidence: 99%

“…It has recently been shown that BYHWD could exposure augmented angiogenetic miRNAs in ischemic stroke 24. Additionally, we first found that lncRNAs were possible therapeutic targets of BYHWD in ICH treatment 25, 26. Nevertheless, considering a huge amount of ncRNAs, more functional ncRNAs are needed to reveal the therapeutic mechanisms of BYHWD in ICH.…”

Section: Introductionmentioning

confidence: 95%

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Systematic Analysis of tRNA-Derived Small RNAs Reveals Novel Potential Therapeutic Targets of Traditional Chinese Medicine (Buyang-Huanwu-Decoction) on Intracerebral Hemorrhage

Li¹,

Tang²,

Liu³

et al. 2019

Int. J. Biol. Sci.

Self Cite

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Although Buyang-Huanwu-Decoction (BYHWD), a famous traditional Chinese medicine, has been utilized to promote the recovery of neurological function in intracerebral hemorrhage (ICH) for centuries, its therapeutic mechanisms remain unclear. tRNA-derived small RNA (tsRNA) is a novel class of short non-coding RNA, possessing potential regulating functions. In the current study, we explored the novel therapeutic targets of BYHWD by tsRNA-sequencing. Rats were randomly divided into three groups: sham, ICH, and BYHWD-treated groups. The modified neurological severity score, corner turn test, foot-fault test, and weight change were used to assess neurological injury. After BYHWD treatment, these behavioral tests were obviously meliorated compared with ICH group in the recovery phase. In the rat brain tissues surrounding the hemorrhagic region, a total of 350 tsRNAs for exact match were identified. 12 of tRNAs (fold change >1.3 and P-value <0.05) were significantly changed in ICH group compared to sham group. Among them, 3 of tRNAs (rno-tRFi-Ser-25a, rno-tRF5-Ala-16a and rno-tRF5-Glu-29a) were markedly regulated by BYHWD treatment and validated with quantitative real-time PCR. Additionally, target prediction and bioinformatics analyses revealed that these tsRNAs could play therapeutic roles through FoxO signaling pathway, positive regulation of long term synaptic depression, autophagy - animal, IL-17 signaling pathway and regulation of cytoskeleton and transforming growth factor beta. In conclusion, tsRNAs are the potential therapeutic targets of BYHWD on ICH treatment. The present study provides novel insights for future investigations to explore the mechanisms, by which BYHWD promotes neurological function recovery after ICH.

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Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction

Pan,

Wang,

Lei

et al. 2024

Phytotherapy Research

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Myocardial infarction (MI) is a prevalent disease with high mortality rates worldwide. The course of MI is intricate and variable, necessitating personalized treatment strategies based on different mechanisms. However, variety of postoperative complications and rejections, such as heart failure, arrhythmias, cardiac rupture, and left ventricular thrombus, contribute to a poor prognosis. Despite the inclusion of antiplatelet agents and statins in the conventional treatment regimen, their clinical applicability is constrained by potential adverse effects and limited efficacy. Additionally, the mechanisms leading to MI are complex and diverse. Therefore, the development of novel compounds for MI treatment. The use of traditional Chinese medicine (TCM) in the prevention and treatment of cardiovascular diseases, including MI, is grounded in its profound historical background, comprehensive theoretical system, and accumulated knowledge. An increasing number of contemporary evidence‐based medical studies have demonstrated that TCM plays a significant role in alleviating symptoms and improving the quality of life for MI patients. Chinese herbal formulations and active ingredients can intervene in the pathological process of MI through key factors such as inflammation, oxidative stress, apoptosis, ferroptosis, pyroptosis, myocardial fibrosis, angiogenesis, and autophagy. This article critically reviews existing herbal formulations from an evidence‐based medicine perspective, evaluating their research status and potential clinical applications. Additionally, it explores recent advancements in the use of herbal medicines and their components for the prevention and treatment of MI, offering detailed insights into their mechanisms of action.

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An Intersectional Study of LncRNAs and mRNAs Reveals the Potential Therapeutic Targets of Buyang Huanwu Decoction in Experimental Intracerebral Hemorrhage

Cited by 20 publications

References 57 publications

Systems biology approaches in the study of Chinese herbal formulae

Systems biology approaches in the study of Chinese herbal formulae

Systematic Analysis of tRNA-Derived Small RNAs Reveals Novel Potential Therapeutic Targets of Traditional Chinese Medicine (Buyang-Huanwu-Decoction) on Intracerebral Hemorrhage

Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction

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