An intestinal zinc sensor regulates food intake and developmental growth

Redhai, Siamak; Pilgrim, Clare; Gaspar, Pedro; Giesen, Lena van; Lopes, Tatiana; Riabinina, Olena; Grenier, Théodore; Milona, Alexandra; Chanana, Bhavna; Swadling, Jacob B.; Wang, Yi Fang; Dahalan, Farah A.; Yuan, Michaela; Wilsch‐Bräuninger, Michaela; Lin, Wei‐Hsiang; Dennison, Nathan; Capriotti, Paolo; Lawniczak, Mara K. N.; Baines, Richard A.; Warnecke, Tobias; Windbichler, Nikolai; Leulier, François; Bellono, Nicholas W.; Miguel-Aliaga, Irene

doi:10.1038/s41586-020-2111-5

Cited by 53 publications

(50 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Insect midgut function seems to be strictly regionalized 52,53 . Cu uptake occurs primarily within the so-called "copper cell region", where, at least in D. melanogaster, Zn was shown to slightly colocalize 33,54 . Nevertheless, the bivalent Zn 2+ does not compete with cellular Cu uptake via the high-affinity Cu + transporter Ctr1 55 .…”

Section: Discussionmentioning

confidence: 99%

“…Feed avoidance due to excessive heavy metal concentrations (> 0.1% Zn 2+ ) is common in terrestrial insects 21 , but was not observed in the present study. Recent observations depict the role of the Zn 2+ -gated midgut sensor Hodor in controlling Drosophila melanogaster s food intake behavior, to ensure insect growth even under macronutrient-scarce conditions 33 . This mechanism, however, seems to be of minor importance in the present study, as mealworms were fed with a rather high-calorie wheat bran diet.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae

Keil

Maares

Kröncke

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The industrial production of Tenebrio molitor L. requires optimized rearing and processing conditions to generate insect biomass with high nutritional value in large quantities. One of the problems arising from processing is a tremendous loss in mineral accessibility, affecting, amongst others, the essential trace element Zn. As a feasible strategy this study investigates Zn-enrichment of mealworms during rearing to meet the nutritional requirements for humans and animals. Following feeding ZnSO4-spiked wheat bran substrates late instar mealworm larvae were evaluated for essential micronutrients and human/animal toxic elements. In addition, growth rate and viability were assessed to select optimal conditions for future mass-rearing. Zn-feeding dose-dependently raised the total Zn content, yet the Znlarvae/Znwheat bran ratio decreased inversely related to its concentration, indicating an active Zn homeostasis within the mealworms. The Cu status remained stable, suggesting that, in contrast to mammals, the intestinal Cu absorption in mealworm larvae is not affected by Zn. Zn biofortification led to a moderate Fe and Mn reduction in mealworms, a problem that certainly can be overcome by Fe/Mn co-supplementation during rearing. Most importantly, Zn feeding massively reduced the levels of the human/animal toxicant Cd within the mealworm larvae, a technological novelty of outstanding importance to be implemented in the future production process to ensure the consumer safety of this edible insect species.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae

Keil

Maares

Kröncke

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Hodor activates the TORC1 signalling pathway, and in doing so, influences organism-wide growth and metabolism. See p.263 2 have identified a membrane-spanning protein, Hodor, that senses zinc ions (Zn 2+ ) in the guts of fruit flies. Following binding by Zn 2+ , Hodor enables passage of chloride ions (Cl � ) into organelles called lysosomes in the cell.…”

Section: Y Rose Citron and Roberto Zoncumentioning

confidence: 99%

“…Silicon's lack of useful optoelectronic capabilities is due to its electronic properties -it is said to be an indirect-bandgap semiconductor. As an example of the problem, solar cells based on silicon must be at least 100 times thicker than those based on gallium arsenide (a direct-bandgap semiconductor, which absorbs and emits light efficiently) to collect the same amount of light, but they still convert the light into electricity much less efficiently 2 . And silicon-based lasers remain an unrealized dream, even after decades of intense research efforts.…”

Section: Gut Cellmentioning

confidence: 99%

See 1 more Smart Citation

A zinc-sensing protein gives flies a gut feeling for growth

Citron¹,

Zoncu²

2020

Nature

View full text Add to dashboard Cite

The cys‐loop ligand‐gated ion channel gene superfamilies of the cockroaches Blattella germanica and Periplaneta americana

Jones

Goven

Froger

et al. 2021

Pest Management Science

View full text Add to dashboard Cite

BACKGROUND Cockroaches are serious urban pests that can transfer disease‐causing microorganisms as well as trigger allergic reactions and asthma. They are commonly managed by pesticides that act on cys‐loop ligand‐gated ion channels (cysLGIC). To provide further information that will enhance our understanding of how insecticides act on their molecular targets in cockroaches, we used genome and reverse transcriptase polymerase chain reaction (RT‐PCR) data to characterize the cysLGIC gene superfamilies from Blattella germanica and Periplaneta americana. RESULTS The B. germanica and P. americana cysLGIC superfamilies consist of 30 and 32 subunit‐encoding genes, respectively, which are the largest insect cysLGIC superfamilies characterized to date. As with other insects, the cockroaches possess ion channels predicted to be gated by acetylcholine, γ‐aminobutyric acid, glutamate and histamine, as well as orthologues of the drosophila pH‐sensitive chloride channel (pHCl), CG8916 and CG12344. The large cysLGIC superfamilies of cockroaches are a result of an expanded number of divergent nicotinic acetylcholine receptor subunits, with B. germanica and P. americana, respectively, possessing eight and ten subunit genes. Diversity of the cockroach cysLGICs is also broadened by alternative splicing and RNA A‐to‐I editing. Unusually, both cockroach species possess a second glutamate‐gated chloride channel as well as another CG8916 subunit. CONCLUSION These findings on B. germanica and P. americana enhance our understanding of the evolution of the insect cysLGIC superfamily and provide a useful basis for the study of their function, the detection and management of insecticide resistance, and for the development of improved pesticides with greater specificity towards these major pests. © 2020 Society of Chemical Industry

show abstract

An intestinal zinc sensor regulates food intake and developmental growth

Cited by 53 publications

References 73 publications

Dietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae

Dietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae

A zinc-sensing protein gives flies a gut feeling for growth

The cys‐loop ligand‐gated ion channel gene superfamilies of the cockroaches Blattella germanica and Periplaneta americana

Contact Info

Product

Resources

About