An intra-oral drug delivery system design for painless, long-term and continuous drug release

Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment. Electronic supplementary materialThe online version of this article (10.1007/s40820-017-0185-x) contains supplementary material, which is available to authorized users.

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Micro- and Nanotechnology-Based Implantable Devices and Bionics

Bisht

Mandal

2017

Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices

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An intra-oral drug delivery system design for painless, long-term and continuous drug release

Cited by 4 publications

References 13 publications

Preparation and Evaluation of a Bio-Erodible Bio-Adhesive Drug Delivery System Designed for Intraoral Extended Release of Flurbiprofen: In Vitro and In Vivo Assessments

Preparation and Evaluation of a Bio-Erodible Bio-Adhesive Drug Delivery System Designed for Intraoral Extended Release of Flurbiprofen: In Vitro and In Vivo Assessments

Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo

Micro- and Nanotechnology-Based Implantable Devices and Bionics

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