2021
DOI: 10.1016/j.ijpharm.2020.119999
|View full text |Cite
|
Sign up to set email alerts
|

An intravenous application of magnetic nanoparticles for osteomyelitis treatment: An efficient alternative

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
13
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 21 publications
(14 citation statements)
references
References 37 publications
0
13
0
Order By: Relevance
“…There are multiple investigations into nanoparticle systems for the treatment of bacterial osteomyelitis designed to overcome the shortcomings of current therapies [ 158 , 190 , 197 , 198 , 199 ]. Posadowska et al [ 197 ] suggested the use of a vancomycin-enriched injectable gellan gum (hydrogel) matrix.…”
Section: Local Drug Delivery Devices For Bacterial Osteomyelitismentioning
confidence: 99%
See 1 more Smart Citation
“…There are multiple investigations into nanoparticle systems for the treatment of bacterial osteomyelitis designed to overcome the shortcomings of current therapies [ 158 , 190 , 197 , 198 , 199 ]. Posadowska et al [ 197 ] suggested the use of a vancomycin-enriched injectable gellan gum (hydrogel) matrix.…”
Section: Local Drug Delivery Devices For Bacterial Osteomyelitismentioning
confidence: 99%
“…Lastly, Ak et al [ 199 ] developed a novel biodegradable, biocompatible, physically targeted gentamicin-loaded gelatin nanoparticle system for the local treatment of bacterial osteomyelitis. Through an in vivo rat model of proximal tibial S. aureus osteomyelitis, the drug delivery system was shown to hasten the recovery time of infected rats in comparison with free gentamicin or placebo therapy.…”
Section: Local Drug Delivery Devices For Bacterial Osteomyelitismentioning
confidence: 99%
“…Stimuli-Responsive Antimicrobial Materials. Over the past decade, there have been numerous advances in the development of stimuli-responsive antimicrobial orthopedic materials that respond to temperature, 23,24 magnetic fields, 25,26 microwaves, 26 and electrical fields, 27 for example. Polymer hydrogels of hyaluronic acid and chitosan have been chemically modified to induce thermoresponsive properties.…”
Section: Recent Advances In Orthopedic Antimicrobial Materials and Pr...mentioning
confidence: 99%
“…Gelatin coated magnetite nanoparticles have been used in conjunction with an external neodymium magnet to guide the location of the injected particles to the target site (implant infection). 25 Additionally, materials that combine several stimuli (e.g., magnetic field, microwaves, temperature) have been engineered to target deep tissue orthopedic implantassociated infections. 26 Magnetic iron oxide (Fe 3 O 4 ) nanoparticles have been combined with carbon nanotubes, antibiotics, and 1-tetradecanol for a "bacterial-capturing" stimuli-responsive system.…”
Section: Recent Advances In Orthopedic Antimicrobial Materials and Pr...mentioning
confidence: 99%
“…Osteomyelitis is an in ammation of the bone caused by infective micro-organisms. The usual treatment of osteomyelitis mainly involves fundamental surgical debridement of the infected bone, lling the bone defect, adequate soft tissue coverage and antibiotic therapy [1][2][3][4]. A prolonged course of antibiotic therapy is required, most often weeks and sometimes longer.…”
Section: Introductionmentioning
confidence: 99%