An Intrinsic Rhythm of Urinary Calcium Excretion and the Specific Effect of Bedrest on the Excretory Pattern

Moore‐Ede, Martin C.; Faulkner, Madelaine; Tredre, Barbara E.

doi:10.1042/cs0420433

Cited by 27 publications

(4 citation statements)

References 13 publications

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“…Discovery of the molecular clock components provided evidence that this predictive homeostasis occurs due to the activity of the circadian clock; the clock allows the body to keep track of the time using multiple cues such as light and food intake. While laying down at night suppresses urinary sodium, potassium, and water excretion, excretion is not suppressed by laying down during the day (Ede et al, 1972). The body predicts we are going to bed at night and prevents loss of precious nutrients.…”

mentioning

confidence: 99%

The Circadian Clock in the Regulation of Renal Rhythms

Solocinski

Gumz

2015

J Biol Rhythms

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Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood pressure, renal blood flow, glomerular filtration rate, and sodium and water excretion have been documented for decades, if not longer. Recent studies on the role of circadian clock proteins in the regulation of a variety of renal transport genes suggest that the molecular clock in the kidney controls circadian fluctuations in renal function. The circadian clock appears to be a critical regulator of renal function with important implications for the treatment of renal pathologies which include chronic kidney disease and hypertension. The development, regulation, and mechanism of the kidney clock are reviewed here.

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confidence: 99%

The Circadian Clock in the Regulation of Renal Rhythms

Solocinski

Gumz

2015

J Biol Rhythms

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“…Kidney regulates the maintenance of uid and ion homeostasis through ltering the blood and blood pressure as consequence [36,37]. Circadian clocks genes have been demonstrated to govern kidney physiology and function at the molecular level [37].…”

Section: Discussionmentioning

confidence: 99%

Circadian Misalignment Leads to Changes in Cortisol Rhythms, Blood Biochemical Variables and Serum miRNA Profiles

Huang¹,

Ma²,

Gan³

et al. 2021

Preprint

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Background: Circadian clock plays a critical role in synchronizing the inner molecular, metabolic and physiological processes to the environmental cues which cycle with a period of 24 h. Misalignment in the circadian rhythms leads to decrease in adaptation, performance and increased risk of associated disorders. The non-24-h schedules and shift schedules are commonly used in maritime operations, both of which could result in disturbance in circadian rhythms. The comprehensive effects of these schedules remain to be further elucidated.Methods: In this study, we firstly conducted an experiment in which the volunteers followed a 3-d rotary schedule with consecutive shift in sleep time (rotatory schedule), and analyzed the changes in salivary cortisol rhythms and blood variables. Next we conducted another experiment in which the volunteers followed an 8 h on and 4 h off schedule (non-24-h schedule) to compare the changes in blood/serum variables. Furthermore, the plasma miRNAs from the volunteers following the rotatory schedule were subject for miRNA sequencing. Results: The rotatory schedule led to elevated levels of serum cortisol during the early stage, and the phase became delayed during the early and stages. The results show both of the schedules caused comprehensive changes in blood/serum biochemical variable, and consistently, the increase in phosphate levels. In addition, a subset of serum miRNAs targeting genes involved in circadian rhythms, sleep homeostasis and multiple important physiological processes or pathways were identified in the experiment with rotatory schedule.Conclusions: This study revealed an increased stress during the rotatory schedule. Circadian misalignment caused by either non-24-h or rotatory schedule lead to extensive changes in blood/serum variables. As to the rotatory schedule, altered expression of serum miRNAs may account for the consequences of circadian misalignment. These findings would help understand the deleterious effects of shift schedules and optimize to enhance performance and welfare of the personnel working with similar schedules.

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“…Urinary phosphate excretion might increase as a direct result of increased phosph oru s intake (either oral or parenteral ), thus exceeding the format ion product for calcium phosphate (44) . Normal 24 -h ur in ar y determinations are not totally reassuring, since there is a marked circadian rhythm to calci um excretion (50). The urin e may become supersat urated interm ittently.…”

Section: Speculationmentioning

confidence: 99%

Nephrolithiasis in Childhood Inflammatory Bowel Disease

Clark,

Fitzgerald,

Bergstein

1985

J. pediatr. gastroenterol. nutr.

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Summary:Six children with inflammatory bowel disease and nephrolithiasis are reported. Their mean age at the passage of the first stone was 12.5 years and the mean duration of active inflammatory bowel disease was 34.5 months. Four had ulcerative colitis and two had Crohn's disease. In three patients the onset of stone disease was associated with a flare in the bowel disease. Stone passage in four patients was accompanied by an increase in abdominal pain; three experienced gross hematuria. Stones from four of the patients were composed primarily of calcium phosphate; stones from the remaining patients contained uric acid and/or calcium oxalate. The pathogenesis of nephrolithiasis as it relates to inflammatory bowel disease is considered and an approach to therapy offered.

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An Intrinsic Rhythm of Urinary Calcium Excretion and the Specific Effect of Bedrest on the Excretory Pattern

Cited by 27 publications

References 13 publications

The Circadian Clock in the Regulation of Renal Rhythms

The Circadian Clock in the Regulation of Renal Rhythms

Circadian Misalignment Leads to Changes in Cortisol Rhythms, Blood Biochemical Variables and Serum miRNA Profiles

Nephrolithiasis in Childhood Inflammatory Bowel Disease

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