An introduction to biomaterial-based strategies for curbing autoimmunity

Lewis, Jamal S.; Allen, Riley

doi:10.1177/1535370216650294

Cited by 9 publications

(13 citation statements)

References 80 publications

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“…6,7 In the same vein, tolerogenic DCs (tDCs) can promote central and peripheral tolerance via a number of mechanisms, including T cell anergy, T reg generation, and effector T cell deletion. 6 Tolerogenic DCs are characterized by low expression of MHCII, CD80, CD86, secretion of anti-inflammatory cytokines (e.g., IL-10), and increased expression of tyrosine-based inhibitory motifs (ITIMs) containing surface receptors and ligands (e.g., ILT-3). The tolerogenic capacity of DCs has spurred investigation into their potential application as live “anti-vaccines” against autoimmune conditions.…”

Section: Introductionmentioning

confidence: 99%

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

Allen

Bolandparvaz

Jeffrey

et al. 2018

ACS Biomater. Sci. Eng.

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Use of biomaterials to spatiotemporally control the activation of immune cells is at the forefront of biomedical engineering research. As more biomaterial strategies are employed for immunomodulation, understanding the immunogenicity of biodegradable materials and their byproducts is paramount in tailoring systems for immune activation or suppression. Poly(D,L-lactic-co-glycolic acid) (PLGA), one of the most commonly studied polymers in tissue engineering and drug delivery, has been previously described on one hand as an immune adjuvant, and on the other as a nonactivating material. In this study, the effect of PLGA microparticles (MPs) on the maturation status of murine bone marrow-derived dendritic cells (DCs), the primary initiators of adaptive immunity, was investigated to decipher the immunomodulatory properties of this biomaterial. Treatment of bone marrow-derived DCs from C57BL/6 mice with PLGA MPs led to a time dependent decrease in the maturation level of these cells, as quantified by decreased expression of the positive stimulatory molecules MHCII, CD80, and CD86 as well as the ability to resist maturation following challenge with lipopolysaccharide (LPS). Moreover, this immunosuppression was dependent on the molecular weight of the PLGA used to fabricate the MPs, as higher molecular weight polymers required longer incubation to produce comparable dampening of maturation molecules. These phenomena were correlated to an increase in lactic acid both intracellularly and extracellularly during DC/PLGA MP coculture, which is postulated to be the primary agent behind the observed immune inhibition. This hypothesis is supported by our results demonstrating that resistance to LPS stimulation may be due to the ability of PLGA MP-derived lactic acid to inhibit the phosphorylation of TAK1 and therefore prevent NF-κB activation. This work is significant as it begins to elucidate how PLGA, a prominent biomaterial with broad applications ranging from tissue engineering to pharmaceutics, could modulate the local immune environment and offers insight on engineering PLGA to exploit its evolving immunogenicity.

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Section: Introductionmentioning

confidence: 99%

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

Allen

Bolandparvaz

Jeffrey

et al. 2018

ACS Biomater. Sci. Eng.

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“…An emerging, biomaterial-based strategy for manipulation of the immune system is controlled release of immunomodulatory agents from particulates [78]. Along this line, Lewis and coworkers have developed biomaterial-based systems for targeting and tolerogenic conditioning of DCs [70, 79, 80].…”

Section: Implant-based Modulation Of DC Activitymentioning

confidence: 99%

Dendritic cells in the host response to implanted materials

Keselowsky

Lewis

2017

Seminars in Immunology

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The role of dendritic cells (DCs) and their targeted manipulation in the body’s response to implanted materials is an important and developing area of investigation, and a large component of the emerging field of biomaterials-based immune engineering. The key position of DCs in the immune system, serving to bridge innate and adaptive immunity, is facilitated by rich diversity in type and function and places DCs as a critical mediator to biomaterials of both synthetic and natural origins. This review presents current views regarding DC biology and summarizes recent findings in DC responses to implanted biomaterials. Based on these findings, there is promise that the directed programming of application-specific DC responses to biomaterials can become a reality, enabling and enhancing applications almost as diverse as the larger field of biomaterials itself.

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“…Vaccine efficacy hinges upon successful delivery of antigen and adjuvant to the correct cell types with high spatial and temporal accuracy. [ 98,99 ] As such, the route of injection is a critical factor affecting the success of a vaccine. Typical vaccine injection routes are intramuscular or subcutaneous due to ease of administration.…”

Section: Vaccines and Immunity—an Overviewmentioning

confidence: 99%

Stimuli‐Responsive Biomaterials for Vaccines and Immunotherapeutic Applications

Pacifici

Bolandparvaz

Lewis

2020

Advanced Therapeutics

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The immune system is the key target for vaccines and immunotherapeutic approaches aimed at blunting infectious diseases, cancer, autoimmunity, and implant rejection. However, systemwide immunomodulation is undesirable due to the severe side effects that typically accompany such strategies. In order to circumvent these undesired, harmful effects, scientists have turned to tailorable biomaterials that can achieve localized, potent release of immune‐modulating agents. Specifically, “stimuli‐responsive” biomaterials hold a strong promise for delivery of immunotherapeutic agents to the disease site or disease‐relevant tissues with high spatial and temporal accuracy. This review provides an overview of stimuli‐responsive biomaterials used for targeted immunomodulation. Stimuli‐responsive or “environmentally responsive” materials are customized to specifically react to changes in pH, temperature, enzymes, redox environment, photo‐stimulation, molecule‐binding, magnetic fields, ultrasound‐stimulation, and electric fields. Moreover, the latest generation of this class of materials incorporates elements that allow for response to multiple stimuli. These developments, and other stimuli‐responsive materials that are on the horizon, are discussed in the context of controlling immune responses.

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An introduction to biomaterial-based strategies for curbing autoimmunity

Cited by 9 publications

References 80 publications

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles

Dendritic cells in the host response to implanted materials

Stimuli‐Responsive Biomaterials for Vaccines and Immunotherapeutic Applications

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