An Introduction to Medical Mycology

Lewis, George M.; Hopper, Mast E.

doi:10.1097/00000441-194002000-00033

Cited by 65 publications

(19 citation statements)

References 0 publications

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“…Three of the patients showed an immediate positive reaction, but their clinical profile was not in any significant way different from those who had negative reactivity. Negative or immediate positive reaction to trichophytin has generally been associated with chronic T. rubrum infections [3,9,15], The specificity of immediate reactivity to trichophytin is limited because it has also been observed in non-infected healthy individuals [15], in atopic individuals [11], in individuals with re current erysipelas-like eruptions [14] and in recurrent lymphangitis [6].…”

Section: Discussionmentioning

confidence: 99%

A Study of the Immunological Status of Patients with Dermatophytoses

Abraham¹,

Pandhi²,

Kumar³

et al. 1975

Dermatology

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22 patients with Trichophyton rubrum infection were studied for some of their immunological parameters. The trichophytin skin test performed with commercially available Dermatophytin (Hollister-Stier) gave immediate positive reaction in 3 patients. All the other patients gave negative delayed and retarded reactions. In vitro response to PHA of the peripheral lymphocytes was significantly depressed in patients as compared to the controls. No relationship could, however, be established between the severity, duration or extent of the disease and the depression of the lymphocyte response. IgG and IgA were found to be within normal limits. IgM levels were significantly depressed which was probably artefactual in nature.

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Section: Discussionmentioning

confidence: 99%

A Study of the Immunological Status of Patients with Dermatophytoses

Abraham¹,

Pandhi²,

Kumar³

et al. 1975

Dermatology

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“…For transmission electron microscopy, the specimens were subsequently postfixed in 0.1 M phosphate buffered in 2% osmium tetroxide [13] at pH 7.4 for I Vi-2 h at room temperature, and were then rapidly dehydrated in a graded series of ethanol, and finally in propylene oxide for 5-10 min, and then embedded in Epon [12].…”

Section: Methodsmentioning

confidence: 99%

“…Konrad and Wolf [ 12], however, failed to confirm these results. Fitzpatrick [9] and Levv/y [13] pointed out that M. furfur may filter ultraviolet light and consequently prevent tan ning of the infected area. However, the depigmentation of the genital area in Negro Jamaican babies secondary to tinea versicolor infection [18] and the observation of multiple hypopigmented patches of tinea versicolor on the shaft of the penis [5] make this hypothesis unacceptable.…”

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confidence: 99%

Tinea versicolor: Ultrastructural Studies on Hypopigmented and Hyperpigmented Skin

et al. 1981

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Punch biopsy specimens from 4 patients with confirmed diagnosis of tinea versicolor were investigated. Hypopigmented, hyperigmented and uninvolved sites from the same subject were compared in relation to ultrastructural alterations as a result of infection with Malassezia furfur, by light, scanning, and transmission electron microscopy. Hyperpigmented skin had thicker stratum corneum than hypopigmented but both were thicker than the uninvolved skin. A large number of tonofilaments were noticed in hyperpigmented sites in stratum granulosum. In hypopigmented skin the melanosomes were individually dispersed and fewer in number than the uninvolved skin. In hyperpigmented skin, the melanosomes were sequestered in most cells suggesting difficulty in the transfer of melanosome granules to keratinocytes. In both cases of pigmentation the most readily affected parts of the cells were cyto-plasmic organelles with a latent effect on the nucleus and nucleolus. We postulate that either stage of pigmentation (hyperpigmentation or hypopigmentation) is an intermediary in nature as a result of M. furfur invasion.

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“…Only L -ew is and Hopper (1943) 5 ) claim to have found a case where the dissease bega:n in the nail-walls. In 15 cases Trichophyton interdigif/alis could be diagnosed and in one case there was a growth of Trichophyton viola.ceum from the nail.…”

Section: Studies Of Findingsmentioning

confidence: 99%