An Introduction to the Cardiac Action Potentials

Thong, Elizabeth H.; Ahmed, Ayesha; MacLeod, Kenneth T.

doi:10.1007/978-3-030-24219-0_5

Cited by 1 publication

(2 citation statements)

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“…16 Calcium ions are essential mediators in this mechanism, and the intracellular and extracellular entry and exit of calcium ions are regulated to couple electrical excitation to mechanical contraction during each AP cycle. 36 Hereditary or acquired CVDs can lead to changes in the expression, distribution, and properties of myocardial ion channels, thereby affecting the generation and spread of APs. 37,38 Conversely, variation in nanoscale functional units related to heart disease are usually linked to abnormal ion channel function.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the excitation-contraction coupling phenomenon in the heart is the working mechanism that converts the electrical stimulation of an AP into contraction of cardiomyocytes, which realizes the conversion of chemical signals to mechanical energy . Calcium ions are essential mediators in this mechanism, and the intracellular and extracellular entry and exit of calcium ions are regulated to couple electrical excitation to mechanical contraction during each AP cycle . Hereditary or acquired CVDs can lead to changes in the expression, distribution, and properties of myocardial ion channels, thereby affecting the generation and spread of APs. , Conversely, variation in nanoscale functional units related to heart disease are usually linked to abnormal ion channel function.…”

Section: Introductionmentioning

confidence: 99%

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Micronano Synergetic Three-Dimensional Bioelectronics: A Revolutionary Breakthrough Platform for Cardiac Electrophysiology

Zheng,

Fang,

et al. 2024

ACS Nano

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Cardiovascular diseases (CVDs) are the leading cause of mortality and therefore pose a significant threat to human health. Cardiac electrophysiology plays a crucial role in the investigation and treatment of CVDs, including arrhythmia. The long-term and accurate detection of electrophysiological activity in cardiomyocytes is essential for advancing cardiology and pharmacology. Regarding the electrophysiological study of cardiac cells, many micronano bioelectric devices and systems have been developed. Such bioelectronic devices possess unique geometric structures of electrodes that enhance quality of electrophysiological signal recording. Though planar multielectrode/multitransistors are widely used for simultaneous multichannel measurement of cell electrophysiological signals, their use for extracellular electrophysiological recording exhibits low signal strength and quality. However, the integration of three-dimensional (3D) multielectrode/multitransistor arrays that use advanced penetration strategies can achieve highquality intracellular signal recording. This review provides an overview of the manufacturing, geometric structure, and penetration paradigms of 3D micronano devices, as well as their applications for precise drug screening and biomimetic disease modeling. Furthermore, this review also summarizes the current challenges and outlines future directions for the preparation and application of micronano bioelectronic devices, with an aim to promote the development of intracellular electrophysiological platforms and thereby meet the demands of emerging clinical applications.

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