An Introduction to the Current State of HIV Vaccine Research

Regenmortel, M.H.V. Van

doi:10.4172/2155-6113.s8-e001

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From Basic and Applied Research To Technological Innovation1

Introduction1

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2014

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“…This means that we achieve useful prescriptive knowledge of the immune system only by a prior successful empirical intervention that would lead for instance to protective immunity. This conclusion is at odds with the currently fashionable paradigm that increasing our knowledge of basic immunology on its own would be sufficient to improve our ability to develop an effective HIV-1 vaccine [4].…”

Section: From Basic and Applied Research To Technological Innovationmentioning

confidence: 99%

“…In HIV vaccine research, there is evidence that several prevalent paradigms have not helped the development of the field, and this may partly explain why after 25 years of intensive research efforts, it has not been possible to develop an effective vaccine using classical strategies [3][4][5][6]. One such paradigm is the assumption that HIV-1 epitopes identified by crystallography of complexes of HIV Env bound to affinity -matured neutralizing (n) Mabs are likely to be effective vaccine immunogens able to induce a protective immune response.…”

Section: Introductionmentioning

confidence: 99%

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