An Introductory to Fasciolosis

Alemneh, Tewodros; Getabalew, Mebrate; Akeberegn, Dawit

doi:10.32474/cdvs.2019.02.000139

Cited by 3 publications

(8 citation statements)

References 4 publications

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“…Animals become infected with Fasciola when they were ingested vegetation contaminated with metacercariae and the disease can present in acute, subacute, or chronic forms, but the chronic form being the most prevalent in cattle. (Bista et al 2018;Alemneh et al 2019). Human beings could get the infection by drinking defiled water containing reasonable metacercariae (Chan and Lam 1987).…”

Section: Discussionmentioning

confidence: 99%

The Infection Rate of Fasciola and Anaplasma in Cattle and Buffaloes in Qena, Egypt

2022

Int J Vet Sci

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Fascioliasis is caused by two species of trematodes that mainly affect the liver. It belongs to the group of foodborne disease infections. It is a zoonotic disease, while anaplasmosis is a tick-borne disease. Both diseases occur worldwide, particularly in regions with intensive animal production. Therefore, the current study aimed to investigate the incidence rate of Fasciola and Anaplasma infections among cattle and buffalo in a part of southern Egypt, “Qena province,” in different seasons among male and female animals with special reference to the harmful effects of Fasciola in the liver of infected animals. The study was carried out from January 2020 to January 2021. A total of 437 cattle and 188 buffaloes of mixed breeds with an age range from 1 to 3 years were selected randomly for the study. Fecal samples were obtained and analyzed for the presence of fluke eggs using direct smear, flotation, and sedimentation techniques. Samples of liver fluke were collected from the liver of slaughtered animals for histopathology. The results revealed that fascioliasis incidence among cattle and buffalo in Qena was 3.43 and 4.26%, respectively. The microscopic examination of blood smears from cattle and buffaloes revealed that 7.5% had an Anaplasma infection; in addition, the infection rate concerning gender indicated that it was higher in females 7.57% than males 6.67%. The findings of fascioliasis and anaplasmosis in farm animals indicate that the danger of both diseases in farm animals, which affects the economic production of animals, increases the risk of infection with zoonotic agents for farmworkers.

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Section: Discussionmentioning

confidence: 99%

The Infection Rate of Fasciola and Anaplasma in Cattle and Buffaloes in Qena, Egypt

2022

Int J Vet Sci

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“…Fascioliasis is considered as food and water borne zoonotic infection caused by digenean trematodes of the genus Fasciola (Alemneh 2019). Fasciola (F.) hepatica (Linnaeus 1758) and Fasciola (F.) gigantica (Cobbold 1856) are the common and more prevalent flukes causing infection in human and animals (Admassu et al 2015;Amer et al 2016).…”

Section: Etiologymentioning

confidence: 99%

“…The high transmission capacity of vectors is connected to the duration and persistence of the life span of the infected snails after infection (Mas-Coma et al 2001). Humans act as the incidental hosts for liver flukes (Alemneh 2019). Ingestion of freshwater wild plants including watercress is the main source of infection to humans (Mas-Coma et al 2018).…”

Section: Transmissionmentioning

confidence: 99%

“…Additionally, metacercariae from different livestock species origins do not show significant differences in definitive host infectivity (Valero and Mas-Coma 2000;Valero et al 2002). The occurrence of fascioliasis in humans has increased in the past 20 years, due to the global increase in the number of infected humans and animals (Alemneh 2019). Previous studies have demonstrated the significant role of human in the spreading of fascioliasis, especially in hyperendemic zones (Esteban et al 1997), particularly where outdoor defecation is practiced (Mas-Coma et al, 1999), or where the correct services for waste and sewage disposal are absent (Hillyer and Apt 1997).…”

Section: Epidemiologymentioning

confidence: 99%

“…Donkey and mules can also harbor the flukes and become a reservoirs host (Meray Sierra 2020). In addition, the fluke was reported from pigs, alpacas, kangaroos, wallabies, and rabbits (Alemneh 2019). The occurrence of Fasciolaiasis depends on several factors related to the biology of vectors and parasites, and the management of animal herds (Khoramian et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Fascioliasis

2023

IJAB

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Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

et al. 2023

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Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of synthetic derivatives of hederagenin, isolated in bulk from Hedera helix. Thirty-six compounds were initially screened against F. hepatica newly excysted juveniles (NEJs) of the Italian strain. Eleven of these compounds were active against NEJs and were selected for further study, using adult F. hepatica derived from a local abattoir (provenance unknown). From these eleven compounds, six demonstrated activity and were further assessed against immature liver flukes of the Italian strain. Subsequently, the most active compounds (n = 5) were further evaluated in ex vivo dose response experiments against adult Italian strain liver flukes. Overall, MC042 was identified as the most active molecule and the EC50 obtained from immature and adult liver fluke assays (at 24 h post co-culture) are estimated as 1.07 μM and 13.02 μM, respectively. When compared to the in vitro cytotoxicity of MDBK bovine cell line, MC042 demonstrated the highest anthelmintic selectivity (44.37 for immature and 3.64 for adult flukes). These data indicate that modified hederagenins display properties suitable for further investigations as candidate flukicides.

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An Introductory to Fasciolosis

Cited by 3 publications

References 4 publications

The Infection Rate of Fasciola and Anaplasma in Cattle and Buffaloes in Qena, Egypt

The Infection Rate of Fasciola and Anaplasma in Cattle and Buffaloes in Qena, Egypt

Fascioliasis

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

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