An intuitive thermal-induced surface zwitterionization for versatile, well-controlled haemocompatible organic and inorganic materials

Sin, Mei-Chan; Lou, Pei-Tzu; Cho, Chia-He; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Chang, Yung

doi:10.1016/j.colsurfb.2015.01.011

Cited by 15 publications

(9 citation statements)

References 31 publications

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“…97 Finally, a third grafting from technique that we used for surface zwitterionization is thermally induced polymerization. 93 Among the advantages of this common technique, biomaterial surfaces can be functionalized without using a catalyst or toxic solvents. We applied this method to silicon wafers that were first grafted with organosilane molecules.…”

Section: ■ Zwitterionic Molecular Designsmentioning

confidence: 99%

Designs of Zwitterionic Interfaces and Membranes

Venault

Chang

2018

Langmuir

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Zwitterionic materials are the latest generation of materials for nonfouling interfaces and membranes. They outperform poly(ethylene glycol) derivatives because they form tighter bonds with water molecules and can trap more water molecules. This feature article summarizes our laboratory's fundamental developments related to the functionalization of interfaces and membranes using zwitterionic materials. Our molecular designs of zwitterionic polymers and copolymers, sulfobetaine-based, carboxybetaine-based, or phosphobetaine-based, are first reviewed. Then, the strategies used to functionalize surfaces/membranes by coating, grafting onto, grafting from, or in situ modification are examined and discussed, and the third part of this article shifts the focus to key applications of zwitterionic materials. Finally, some potential future directions for molecular designs, functionalization processes, and applications are presented.

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Section: ■ Zwitterionic Molecular Designsmentioning

confidence: 99%

Designs of Zwitterionic Interfaces and Membranes

Venault

Chang

2018

Langmuir

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“…The marked decrease in contact angle for both SBMA-and CBMA-coated surfaces indicates increases in hydrophilicity and further corroborates that the surface was successfully functionalized with the zwitterionic polymer. These decreases in contact angle are consistent with the results of an SBMA polymer grafted from silicon wafers using thermally-initiated polymerization 251. The observation that the contact angle of the substrates remain constant at higher concentrations (Figure 5.4) implies that at a solution concentration of 1 wt% the surface has reached a maximal coverage: i.e., virtually all accessible methacrylate groups on the surface have reacted with the zwitterionic monomer.…”

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confidence: 84%

Engineering surfaces using photopolymerization to improve cochlear implant materials

Leigh¹

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my success as a graduate student. His dedication to my success in research and development as a professional have been constant and indispensable to my career. Dr. Guymon has helped me to substantially improve my technical communication skills, both writing and presenting, by providing invaluable feedback on manuscripts and presentations. He also provided me with a great undergraduate research experience for a summer as an REU student. Dr. Guymon's ambitious attitude is infectious and encouraged me to present my research and network with professionals from science and engineering. Dr. Marlan Hansen has also been an excellent mentor and collaborator during my graduate school experience. His contribution to the research project and this work have been significant and indispensable. I have enjoyed his optimism and creativity in meeting the challenges associated with graduate school. I am so grateful for his attitude and humor through stressful times and his willingness to mentor me individually, both professionally and personally. More could be said about his influence and guidance on my graduate school experience but suffice it to say that I am profoundly grateful for his mentorship. There have also been many outstanding members from Dr. Hansen's research lab who were invaluable to the project. Linjing

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“…Early studies on material surface modifications were performed with single zwitterions, but macromolecular approaches have gained increasing importance mainly because polyzwitterions provide a more robust coating and are more efficient at blocking original surface ions (44, 45). This finding has received strong support by adsorption experiments of fibrinogen and cells such as fibroblasts or platelets on surfaces with different coverage of pSBE or pCB brushes, where the capability to prevent fouling correlated with the degree of grafting (46–48). Furthermore, the surface roughness can be effectively smoothed by brush grafting with additional positive effects on material biocompatibility (49).…”

Section: Polyzwitterions: Beyond Antifoulingmentioning

confidence: 91%

Biomimetic Principles to Develop Blood Compatible Surfaces

2017

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Functionalized biomaterial surface patterns capable of resisting nonspecific adsorption while retaining their bioactivity are crucial in the advancement of biomedical technologies, but currently available biomaterials intended for use in whole blood frequently suffer from nonspecific adsorption of proteins and cells, leading to a loss of activity over time. In this review, we address two concepts for the design and modification of blood compatible biomaterial surfaces, zwitterionic modification and surface functionalization with glycans - both of which are inspired by the membrane structure of mammalian cells - and discuss their potential for biomedical applications.

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An intuitive thermal-induced surface zwitterionization for versatile, well-controlled haemocompatible organic and inorganic materials

Cited by 15 publications

References 31 publications

Designs of Zwitterionic Interfaces and Membranes

Designs of Zwitterionic Interfaces and Membranes

Engineering surfaces using photopolymerization to improve cochlear implant materials

Biomimetic Principles to Develop Blood Compatible Surfaces

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