An Inverse Association between Serum Gamma Glutamyl Transpeptidase Activity and Breslow's Lifestyle Index; Its Practical Application for Screening of Subjects with Unhealthy Lifestyles

Abstract

An Inverse Association between SerumGamma Glutamyl Transpeptidase Activity and Breslow's Lifestyle Index; Its Practical Application for Screening of Subjects with Unhealthy Lifestyles: Hirokazu YOKOYAMA, et al. Health Center, School of Medicine, Keio University-We examined whether serum γGTP activity (γGTP) is associated with Breslow's lifestyle index and whether it could be used as a tool to detect subjects with unhealthy lifestyles. To that effect, 724 male Japanese workers excluding patients suffering from hepatitis virus infection, autoimmune liver diseases and apparently active bile duct diseases were cross-sectionally examined. γGTP was inversely associated with the total score of Breslow's index for all subjects (λ=30.643) and in subjects aged 40 or more (λ=37.073). The association was consistent even after adjustments of subjects' ages and levels of triglycerides, total cholesterol and uric acid (p=0.0001). Among the seven lifestyle factors comprising Breslow's index, improper habits of drinking (p<0.0001), smoking (p=0.0204), exercise (p=0.0189) and body weight control (p<0.0001), were associated with increased γGTP. Even in a survey in which subjects who had proper habits of drinking and body weight control were selectively examined, improper habits of smoking and exercise still tended to be associated with increased γGTP. Receiver operating characteristic curves indicated that γGTP was beneficial for detecting subjects who scored two or less on Breslow's index, at least in subjects aged 40 or more. γGTP was associated with insulin resistance level estimated by the homeostasis model assessment (p<0.0001), which was inversely associated with Breslow's index (p=0.0040). γGTP could be used as an objective substitute of Breslow's index, allowing us to identify subjects with low scores on Breslow's index, at least after sorting subjects properly. Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues. (J Occup Health 2006; 48: 198-206)

What does serum γ-glutamyltransferase tell us as a cardiometabolic risk marker?

“…121 after adjustment for confounding factors. 121 The prevalence of raised serum GGT activity of >78 IU/L was higher (100% and 61.5%, respectively) in subjects who scored only one or two points (one point for every answer denoting healthy lifestyle) based on Breslow's index, compared to 10.8% and 4.2% in subjects who scored six and seven points, respectively. The Breslow's index is a simple and objective tool that could be useful in some cases to identify and improve unhealthy lifestyles.…”

“…The Breslow's index is a simple and objective tool that could be useful in some cases to identify and improve unhealthy lifestyles. 121 The association of serum GGT activity and incidence of diabetes would suggest that measuring serum GGT is easy and inexpensive, and could be useful in the prediction of diabetes in obese and high-risk individuals. It could also be useful in predicting complications such as microalbuminuria in known diabetic patients.…”