“…Data-driven approaches enabled by machine learning (ML) have led to significant progress in many nuclear engineering applications, including reactor performance optimization [8,9,10], transient-state prediction [11,12], anomaly detection [13], data assimilation [14,15], model validation and uncertainty quantification [16,17,18,19,20], and digital twin [21]. Among various ML methods, deep neural networks (DNNs) provide us with an especially promising technical approach to developing a data-driven coarse-mesh turbulence model.…”