An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals

Abstract

High sensitivity C-reactive protein (hs-CRP) is a marker of low-grade sustained inflammation. Omega-3 (n-3) fatty acids have anti-inflammatory properties and are associated with reduced cardiovascular disease (CVD) risk. The aim of this study was to investigate whether plasma n-3 fatty acid concentration is related to hs-CRP concentration. A total of 124 free-living adults, were divided into tertiles of plasma hs-CRP (o1.0, 1.0-3.0 and 43.0 mg/l). Body composition and anthropometric measurements were recorded. Hs-CRP was analysed using immunoassays and fatty acids were measured by gas chromatography. Plasma hs-CRP concentration was negatively correlated with total n-3 fatty acids (P ¼ 0.05), eicosapentaenoic acid (EPA; P ¼ 0.002) and docosapentaenoic acid (DPA; P ¼ 0.01). The highest hs-CRP tertile (43.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (Po0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk.

Beneficial n-3 polyunsaturated fatty acid levels and n6:n3 ratios after 4-week EPA + DHA supplementation associated with reduced CRP: A pilot study in healthy young adults

“…They reported that PUFAs, and especially total n-3, were independently associated with lower levels of pro-inflammatory markers (CRP, IL-6, IL-1ra, and TNFα) and higher levels of anti-inflammatory markers (soluble IL-6r, IL-10, and TGFβ) independent of confounders. Though a systematic review by Balk et al [47] reported mixed effects of n-3 PUFAs on serum markers of CVD risk, the present study findings are more in agreement with the many studies reporting an inverse relationship between the intake of n-3 and biomarkers of inflammation in healthy subjects and other human trials [48][49][50][51][52]. Collectively, these studies support the significant benefits of increasing low n-3 PUFA levels to help balance the n-6:n-3 ratio, and our results indicate that it is possible to achieve this goal efficiently with four weeks of n-3 EPA and DHA oral supplements in a young adult sample, and that this was associated with reduced CRP.…”

Eicosapentaenoic Acid (EPA) Reduces Cardiovascular Events: Relationship with the EPA/Arachidonic Acid Ratio

“…5). In contrast, the plasma high-sensitivity CRP and EPA concentrations exhibit a negative correlation 99) . The administration of hp-EPA-E (Epadel ship between EPA and CVD, and the JELIS study recently demonstrated that EPA administration reduces the risk of CVD.…”

Phylogenesis, Etiology and Pathogenesis of Insulin Resistance. Differences From Type Ii Diabetes Mellitus

“…Поэтому содержание НЭЖК+АЛБ в сыворотке крови, увели-чение содержания СРБ в субклиническом (клиническом) интервале, гипертриглицеридемию, повышение в плазме крови содержания тиреоидных гормонов, гормона роста, глюкокортикоидов и эстрогенов можно рассматривать как маркеры патофизиологичных состояний, которые формируют резистентность к ИНС [45,46]. Если в плазме крови повышено содержание СРБ, это можно рассма-тривать как тест РИ; к тому же, СРБ негативно соотно-сится с содержанием в плазме крови ω-3 ЭС-поли-ЖК [47]. Уровень ХС в ЛП не помогает диагностике РИ [48].…”