2021
DOI: 10.1007/s12020-021-02635-y
|View full text |Cite
|
Sign up to set email alerts
|

An inverted U-shaped relationship between parathyroid hormone and body weight, body mass index, body fat

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
7
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 9 publications
(9 citation statements)
references
References 45 publications
2
7
0
Order By: Relevance
“…Conversely, we found that TAT and VAT all were negatively correlated with BMD in both the PHPT group and HCs, but the causal relationship between fat metabolism and BMD remains to be studied. An earlier study (28) and the current study found that PTH level was correlated with VAT and BMD, moreover, it has been well-documented that both are the main target organs of PTH. Furthermore, after adjustment for age and PTH, the multiple linear regression analysis showed that neither TAT nor VAT were significantly correlated with BMD.…”
Section: Discussionsupporting
confidence: 66%
“…Conversely, we found that TAT and VAT all were negatively correlated with BMD in both the PHPT group and HCs, but the causal relationship between fat metabolism and BMD remains to be studied. An earlier study (28) and the current study found that PTH level was correlated with VAT and BMD, moreover, it has been well-documented that both are the main target organs of PTH. Furthermore, after adjustment for age and PTH, the multiple linear regression analysis showed that neither TAT nor VAT were significantly correlated with BMD.…”
Section: Discussionsupporting
confidence: 66%
“…This behavior could be explained as a consequence of hypercalcemia or malnutrition due to gastro-intestinal manifestation of hyperPTH. Alternatively, animal studies provided evidence that exposure to high levels of PTH can induce increased expression of thermogenesis genes, resulting in white adipose browning and muscle wasting [ 24 , 25 ].
Fig.
…”
Section: Methodsmentioning
confidence: 99%
“…Many clinical studies have shown that the associations between all-cause mortality, as well as other patient-level parameters (such as cardiovascular events, body weight, body mass index, and body fat), and iPTH are U-shaped ( Figure 4 ), with increased risk at both ends, i.e., too low or too high iPTH [ 50 , 51 , 52 , 53 , 54 ]. Moreover, it was reported that iPTH shows an almost perfect correlation with oxPTH ( Figure 4 ) and a relatively weaker correlation with noxPTH [ 41 , 45 , 48 ].…”
Section: Conclusion and Open Questionsmentioning
confidence: 99%
“… All-cause mortality curve of iPTH and its correlation with oxPTH and noxPTH. The U-shaped association is derived from the following publications: [ 50 , 51 , 52 , 53 , 54 ], and the correlation data are derived from the EVOLVE trial [ 45 ]. Other smaller studies [ 41 , 48 ] showed comparable correlations too.…”
Section: Figurementioning
confidence: 99%