An investigation into signal transduction mechanisms involved in DHPG-induced LTD in the CA1 region of the hippocampus

Schnabel, Rebecca; Kilpatrick, Ian C.; Collingridge, Graham L.

doi:10.1016/s0028-3908(99)00062-3

Cited by 74 publications

(58 citation statements)

References 31 publications

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“…mGlu receptor-dependent LTD in the CA1 region can be induced by particular stimulation protocols (e.g., by paired-pulse lowfrequency stimulation; PP-LSF) or, alternatively, by direct application of group-I mGlu receptor agonists to hippocampal slices (Fitzjohn et al, 1996;Overstreet et al, 1997;Palmer et al, 1997;Schnabel et al, 1999;Huber et al, 2000). The latter strategy carries the advantage of selectively activating group-I mGlu receptors, although it should be kept in mind that there may be some differences in the molecular events underlying the induction and expression of DHPG/LTD and PP-LFS-induced mGlu receptordependent LTD (reviewed by Kemp and Bashir, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…DHPG-induced LTD at the Schaffer collateral-CA1 synapses is insensitive to inhibitors of phospholipase C␤ (Huang and Hsu, 2006), inhibitors of protein kinase C (Schnabel et al, 1999), intracellular Ca 2ϩ chelators (Fitzjohn et al, 2001;Ireland and Abraham, 2009), or agents that deplete intracellular Ca 2ϩ stores (Schnabel et al, 1999). Thus, it is unlikely that amplification of PI hydrolysis mediates the synergism between clustered EphB1/Fc and DHPG on synaptic depression.…”

Section: Discussionmentioning

confidence: 99%

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Interaction between Ephrins and mGlu5 Metabotropic Glutamate Receptors in the Induction of Long-Term Synaptic Depression in the Hippocampus

Piccinin¹,

Cinque²,

Calò³

et al. 2010

J. Neurosci.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interaction between Ephrins and mGlu5 Metabotropic Glutamate Receptors in the Induction of Long-Term Synaptic Depression in the Hippocampus

Piccinin¹,

Cinque²,

Calò³

et al. 2010

J. Neurosci.

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“…In addition, activation of M1 muscarinic receptors (coupled to PLC) alone is sufficient to induce an NMDARindependent form of LTD in the perirhinal cortex (Massey et al, 2001). The requirement for PLC activity may not be universal, however, because LTD induced with type I mGluR agonists in the CA1 region may occur independent of the PLC pathway (Schnabel et al, 1999;.…”

Section: Discussionmentioning

confidence: 99%

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Choi¹,

Chang²,

Jiang³

et al. 2005

J. Neurosci.

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Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of ␣1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular D-myo-inositol-1,4,5-triphosphate (IP 3 ). LTD was also impaired by intracellular application of PLC or IP 3 receptor blockers, and it was absent in mice lacking PLC␤1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism.

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“…Because group 1 mGluRs activate the phospholipase C cascade, it is surprising that protein kinase C inhibitors, depletion of intracellular Ca 2ϩ stores, or postsynaptic Ca 2ϩ chelators do not affect DHPG-induced LTD (DHPG-LTD) (Schnabel et al, 1999;Fitzjohn et al, 2001). Instead, there is a report that tyrosine phosphatase inhibitors block DHPG-LTD (Moult et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1

et al. 2004

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Activation of group 1 metabotropic glutamate receptors (mGluRs) induces long-term depression (LTD) of synaptic transmission that relies on dendritic protein synthesis. We investigated the signal transduction pathways required for mGluR-LTD to identify candidate mechanisms for mGluR regulation of synaptic protein synthesis. Our results demonstrate a role for extracellular signal-regulated protein kinase (ERK), a subclass of the mitogen-activated protein kinases (MAPKs), in mGluR-LTD in area CA1 of the rat hippocampus. Inhibitors of the upstream kinase of ERK, MAP/ERK kinase significantly reduce mGluR-LTD induced by the group 1 agonist dihydroxyphenylglycine (DHPG) and synaptic stimulation but do not affect NMDA receptor-dependent LTD. In contrast, inhibitors of p38 MAPK were ineffective against DHPG-induced LTD. Consistent with the role of ERK in mGluR-LTD, we observed that DHPG treatment of hippocampal slices (isolated CA1), at concentrations that induce LTD, results in a robust phosphorylation of ERK but not of p38 MAPK. These results point to ERK as an important regulator of mGluR-LTD and a potential mechanism for mGluR regulation of synaptic protein synthesis.

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An investigation into signal transduction mechanisms involved in DHPG-induced LTD in the CA1 region of the hippocampus

Cited by 74 publications

References 31 publications

Interaction between Ephrins and mGlu5 Metabotropic Glutamate Receptors in the Induction of Long-Term Synaptic Depression in the Hippocampus

Interaction between Ephrins and mGlu5 Metabotropic Glutamate Receptors in the Induction of Long-Term Synaptic Depression in the Hippocampus

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1

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