An Investigation into the Effectiveness of Sacubitril and Valsartan Sodium with Percutaneous Coronary Intervention in Acute Myocardial Infarction

Abstract

To evaluate the effectiveness of emergency percutaneous coronary intervention when used in combination with sacubitril and valsartan sodium for managing patients with acute myocardial infarction. Our randomized controlled trial enrolled 78 patients with acute myocardial infarction treated at our hospital between October 2018 and October 2020. Participants were allocated randomly into two groups; observation group (n=39) received sacubitril and valsartan sodium combined with percutaneous coronary intervention, and the control group (n=39) received enalapril and percutaneous coronary intervention. In our study, in addition to comparing changes in cardiac biomarkers (troponin I and N-terminal pro-brain natriuretic peptide) before and after treatment, we also analyzed adverse reactions and changes in cardiac structure and function. After 6 mo, left ventricular end-diastolic diameter and left ventricular end-systolic diameter of observation group was obviously decreased, while the control group has no significant change. In the aspect of left ventricular ejection fraction, the observation group increased significantly, while the control group had no significant change. In the N-terminal pro-brain natriuretic peptide serum levels and the incidence of heart failure, the observation group showed advantages, compared with the control group. Sacubitril and valsartan sodium combined with emergency percutaneous coronary intervention can improve cardiac structural and functional indices, reduce the risk of heart failure, and increase long-term survival time in acute myocardial infarction patients. This approach is safe and effective and therefore warrants further consideration in clinical settings.