An Investigation into the Protective Effects of Various Doses of Boric Acid on Liver, Kidney, and Brain Tissue Damage Caused by High Levels of Acute Alcohol Consumption

İlhan, Ayşegül Oğlakçı; Can, Betül; Kar, Fatih; Gündoğdu, Ayşe; Söğüt, İbrahim; Kanbak, Güngör

doi:10.1007/s12011-023-03699-9

Cited by 5 publications

(3 citation statements)

References 50 publications

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“…It is known that boric acid affects the function of the immune system [41]. The need for boric acid can vary greatly due to infection, increased inflammation, and metabolic disorders, and this can be particularly pronounced for malnourished individuals.…”

Section: Discussionmentioning

confidence: 99%

Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats

BAŞEĞMEZ,

DOĞAN

2024

Pam Tıp Derg

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Purpose: As a result of the literature studies, it was seen that boric acid was the subject of many studies, and its effects on living things were investigated and examined. The aim of this study was to investigate the effects of oral boric acid supplementation at pharmacologic doses on physiological and biochemical systems in aged rats. Material and methods: A total of 32 Wistar Albino male-aged rats were randomly and equally divided into the following four groups: 1st; Control=1 ml saline; 2nd; Low-dose boric acid (L-BA)=10 mg/kg; 3rd; Medium-dose boric acid (M-BA)=20 mg/kg; 4th; High-dose boric acid (H-BA)=40 mg/kg. Boric acid was given orally to aged rats for 28 days. Blood, liver, and kidney samples of rats were collected on day 29 to be analyzed for oxidants, antioxidants, proinflammatory cytokines, and biochemical changes. Result: Boric acid significantly increased albumin, total protein, calcium levels equally in all boric acid groups compared to the control group (p

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Section: Discussionmentioning

confidence: 99%

Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats

BAŞEĞMEZ,

DOĞAN

2024

Pam Tıp Derg

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“…However, the underlying mechanisms remain unclear. Many epidemiological studies and experimental reports showed that excessive alcohol intake increases the risk of damage to various tissues such as the liver, gut, and kidneys [ 41 , 42 , 43 ], and could also cause an irreversible impact on the brain [ 44 , 45 , 46 ]. Many laboratories, including ours, reported that binge alcohol intake causes gut leakiness, which is likely to be associated with damage to tissues including the gut, liver, and brain through the gut–liver [ 16 , 17 , 18 , 47 ] or gut brain axes [ 27 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) Protects against Binge Alcohol-Mediated Gut and Brain Injury

Ray,

Rungratanawanich,

LeFort

et al. 2024

Cells

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Mitochondrial aldehyde dehydrogenase-2 (ALDH2) metabolizes acetaldehyde to acetate. People with ALDH2 deficiency and Aldh2-knockout (KO) mice are more susceptible to alcohol-induced tissue damage. However, the underlying mechanisms behind ALDH2-related gut-associated brain damage remain unclear. Age-matched young female Aldh2-KO and C57BL/6J wild-type (WT) mice were gavaged with binge alcohol (4 g/kg/dose, three doses) or dextrose (control) at 12 h intervals. Tissues and sera were collected 1 h after the last ethanol dose and evaluated by histological and biochemical analyses of the gut and hippocampus and their extracts. For the mechanistic study, mouse neuroblast Neuro2A cells were exposed to ethanol with or without an Aldh2 inhibitor (Daidzin). Binge alcohol decreased intestinal tight/adherens junction proteins but increased oxidative stress-mediated post-translational modifications (PTMs) and enterocyte apoptosis, leading to elevated gut leakiness and endotoxemia in Aldh2-KO mice compared to corresponding WT mice. Alcohol-exposed Aldh2-KO mice also showed higher levels of hippocampal brain injury, oxidative stress-related PTMs, and neuronal apoptosis than the WT mice. Additionally, alcohol exposure reduced Neuro2A cell viability with elevated oxidative stress-related PTMs and apoptosis, all of which were exacerbated by Aldh2 inhibition. Our results show for the first time that ALDH2 plays a protective role in binge alcohol-induced brain injury partly through the gut–brain axis, suggesting that ALDH2 is a potential target for attenuating alcohol-induced tissue injury.

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“…Travmatik beyin hasarı oluşturulan Wistar albino sıçanlarda 100 mg/ kg BA uygulamasının MDA düzeylerini, ödem ve nekrotik nöron sayısını azalttığını bildirmişlerdir [67]. Wistar albino sıçanlarda 8 g/kg etanol ile oluşturulan oksidatif stres kaynaklı toksisite modelinde 50 ve 100 mg/kg BA uygulamasının beyin dokusunda MDA ve TOS düzeylerini azalttığı, Total Antioksidan Seviyesi (TAS) düzeylerini arttırdığı bildirilmiştir [68]. 500 ve 1000 mg/kg bakır kaynaklı toksisiteye maruz kalan gökkuşağı alabalığı (Oncorhynchus mykiss)'nın beyin dokusunda 1,25, 2,5, ve 5 mg/kg diyet boraksının nöroprotektif etkilerinin değerlendirildiği bir çalışmada, boraksa maruz bırakılan balık beyinlerindeki SOD, [72].…”

Section: Bor İçeren Bileşiklerin Antiinflamatuar Ve Antioksidan öZel...unclassified

Alzheimer ve Parkinson Hastalıklarında Bor İçeren Bileşiklerin Nörokoruyucu Etkisi

Bitmez,

Balbal

2024

Journal of Boron

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Bu derlemede bor içeren bileşiklerin nörodejenerasyon süreci üzerindeki etkileri anlatılmaktadır. Bor içeren bileşikler nöronlar üzerinde çeşitli koruyucu etkiler gösterirler. Son araştırmalar, bor takviyesinin nöronlarda antioksidan savunma mekanizmalarının artmasına yol açtığını, inflamasyonu baskıladığını ve oksidatif hasara karşı iyi bir koruma potansiyeli sergilediğini göstermiştir. Bu doğrultuda yazılan derleme makalesinde, bor içeren bileşiklerin nöro-koruyucu etkilerinin araştırıldığı çalışmalar incelendi ve bor içeren bileşiklerin nörodejeneratif hastalıkların tedavisinde spesifik hedeflere ilaç olarak uygulanmasına ilişkin daha ileri çalışmalara gerek olduğu tespit edildi.

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An Investigation into the Protective Effects of Various Doses of Boric Acid on Liver, Kidney, and Brain Tissue Damage Caused by High Levels of Acute Alcohol Consumption

Cited by 5 publications

References 50 publications

Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats

Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats

Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) Protects against Binge Alcohol-Mediated Gut and Brain Injury

Alzheimer ve Parkinson Hastalıklarında Bor İçeren Bileşiklerin Nörokoruyucu Etkisi

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